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A Wide Range of 3243A>G/tRNALeu(UUR) (MELAS) Mutation Loads May Segregate in Offspring through the Female Germline Bottleneck

Segregation of mutant mtDNA in human tissues and through the germline is debated, with no consensus about the nature and size of the bottleneck hypothesized to explain rapid generational shifts in mutant loads. We investigated two maternal lineages with an apparently different inheritance pattern of...

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Detalles Bibliográficos
Autores principales:	Pallotti, Francesco, Binelli, Giorgio, Fabbri, Raffaella, Valentino, Maria L., Vicenti, Rossella, Macciocca, Maria, Cevoli, Sabina, Baruzzi, Agostino, DiMauro, Salvatore, Carelli, Valerio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013013/ https://www.ncbi.nlm.nih.gov/pubmed/24805791 http://dx.doi.org/10.1371/journal.pone.0096663

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