Basal Gene Expression by Lung CD4+ T Cells in Chronic Obstructive Pulmonary Disease Identifies Independent Molecular Correlates of Airflow Obstruction and Emphysema Extent

Lung CD4+ T cells accumulate as chronic obstructive pulmonary disease (COPD) progresses, but their role in pathogenesis remains controversial. To address this controversy, we studied lung tissue from 53 subjects undergoing clinically-indicated resections, lung volume reduction, or transplant. Viable...

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Detalles Bibliográficos
Autores principales: Freeman, Christine M., McCubbrey, Alexandra L., Crudgington, Sean, Nelson, Joshua, Martinez, Fernando J., Han, MeiLan K., Washko, George R., Chensue, Stephen W., Arenberg, Douglas A., Meldrum, Catherine A., McCloskey, Lisa, Curtis, Jeffrey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013040/
https://www.ncbi.nlm.nih.gov/pubmed/24805101
http://dx.doi.org/10.1371/journal.pone.0096421

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