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Correlation of Standardized Uptake Value and Apparent Diffusion Coefficient in Integrated Whole-Body PET/MRI of Primary and Recurrent Cervical Cancer

BACKGROUND: To evaluate a potential correlation of the maximum standard uptake value (SUV(max)) and the minimum apparent diffusion coefficient (ADC(min)) in primary and recurrent cervical cancer based on integrated PET/MRI examinations. METHODS: 19 consecutive patients (mean age 51.6 years; range 30...

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Autores principales: Grueneisen, Johannes, Beiderwellen, Karsten, Heusch, Philipp, Buderath, Paul, Aktas, Bahriye, Gratz, Marcel, Forsting, Michael, Lauenstein, Thomas, Ruhlmann, Verena, Umutlu, Lale
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013042/
https://www.ncbi.nlm.nih.gov/pubmed/24804676
http://dx.doi.org/10.1371/journal.pone.0096751
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author Grueneisen, Johannes
Beiderwellen, Karsten
Heusch, Philipp
Buderath, Paul
Aktas, Bahriye
Gratz, Marcel
Forsting, Michael
Lauenstein, Thomas
Ruhlmann, Verena
Umutlu, Lale
author_facet Grueneisen, Johannes
Beiderwellen, Karsten
Heusch, Philipp
Buderath, Paul
Aktas, Bahriye
Gratz, Marcel
Forsting, Michael
Lauenstein, Thomas
Ruhlmann, Verena
Umutlu, Lale
author_sort Grueneisen, Johannes
collection PubMed
description BACKGROUND: To evaluate a potential correlation of the maximum standard uptake value (SUV(max)) and the minimum apparent diffusion coefficient (ADC(min)) in primary and recurrent cervical cancer based on integrated PET/MRI examinations. METHODS: 19 consecutive patients (mean age 51.6 years; range 30–72 years) with histopathologically confirmed primary cervical cancer (n = 9) or suspected tumor recurrence (n = 10) were prospectively enrolled for an integrated PET/MRI examination. Two radiologists performed a consensus reading in random order, using a dedicated post-processing software. Polygonal regions of interest (ROI) covering the entire tumor lesions were drawn into PET/MR images to assess SUV(max) and into ADC parameter maps to determine ADC(min) values. Pearson’s correlation coefficients were calculated to assess a potential correlation between the mean values of ADC(min) and SUV(max). RESULTS: In 15 out of 19 patients cervical cancer lesions (n = 12) or lymph node metastases (n = 42) were detected. Mean SUV(max) (12.5±6.5) and ADC(min) (644.5±179.7×10(−5) mm(2)/s) values for all assessed tumor lesions showed a significant but weak inverse correlation (R = −0.342, p<0.05). When subdivided in primary and recurrent tumors, primary tumors and associated primary lymph node metastases revealed a significant and strong inverse correlation between SUV(max) and ADC(min) (R = −0.692, p<0.001), whereas recurrent cancer lesions did not show a significant correlation. CONCLUSIONS: These initial results of this emerging hybrid imaging technique demonstrate the high diagnostic potential of simultaneous PET/MR imaging for the assessment of functional biomarkers, revealing a significant and strong correlation of tumor metabolism and higher cellularity in cervical cancer lesions.
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spelling pubmed-40130422014-05-09 Correlation of Standardized Uptake Value and Apparent Diffusion Coefficient in Integrated Whole-Body PET/MRI of Primary and Recurrent Cervical Cancer Grueneisen, Johannes Beiderwellen, Karsten Heusch, Philipp Buderath, Paul Aktas, Bahriye Gratz, Marcel Forsting, Michael Lauenstein, Thomas Ruhlmann, Verena Umutlu, Lale PLoS One Research Article BACKGROUND: To evaluate a potential correlation of the maximum standard uptake value (SUV(max)) and the minimum apparent diffusion coefficient (ADC(min)) in primary and recurrent cervical cancer based on integrated PET/MRI examinations. METHODS: 19 consecutive patients (mean age 51.6 years; range 30–72 years) with histopathologically confirmed primary cervical cancer (n = 9) or suspected tumor recurrence (n = 10) were prospectively enrolled for an integrated PET/MRI examination. Two radiologists performed a consensus reading in random order, using a dedicated post-processing software. Polygonal regions of interest (ROI) covering the entire tumor lesions were drawn into PET/MR images to assess SUV(max) and into ADC parameter maps to determine ADC(min) values. Pearson’s correlation coefficients were calculated to assess a potential correlation between the mean values of ADC(min) and SUV(max). RESULTS: In 15 out of 19 patients cervical cancer lesions (n = 12) or lymph node metastases (n = 42) were detected. Mean SUV(max) (12.5±6.5) and ADC(min) (644.5±179.7×10(−5) mm(2)/s) values for all assessed tumor lesions showed a significant but weak inverse correlation (R = −0.342, p<0.05). When subdivided in primary and recurrent tumors, primary tumors and associated primary lymph node metastases revealed a significant and strong inverse correlation between SUV(max) and ADC(min) (R = −0.692, p<0.001), whereas recurrent cancer lesions did not show a significant correlation. CONCLUSIONS: These initial results of this emerging hybrid imaging technique demonstrate the high diagnostic potential of simultaneous PET/MR imaging for the assessment of functional biomarkers, revealing a significant and strong correlation of tumor metabolism and higher cellularity in cervical cancer lesions. Public Library of Science 2014-05-07 /pmc/articles/PMC4013042/ /pubmed/24804676 http://dx.doi.org/10.1371/journal.pone.0096751 Text en © 2014 Grueneisen et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Grueneisen, Johannes
Beiderwellen, Karsten
Heusch, Philipp
Buderath, Paul
Aktas, Bahriye
Gratz, Marcel
Forsting, Michael
Lauenstein, Thomas
Ruhlmann, Verena
Umutlu, Lale
Correlation of Standardized Uptake Value and Apparent Diffusion Coefficient in Integrated Whole-Body PET/MRI of Primary and Recurrent Cervical Cancer
title Correlation of Standardized Uptake Value and Apparent Diffusion Coefficient in Integrated Whole-Body PET/MRI of Primary and Recurrent Cervical Cancer
title_full Correlation of Standardized Uptake Value and Apparent Diffusion Coefficient in Integrated Whole-Body PET/MRI of Primary and Recurrent Cervical Cancer
title_fullStr Correlation of Standardized Uptake Value and Apparent Diffusion Coefficient in Integrated Whole-Body PET/MRI of Primary and Recurrent Cervical Cancer
title_full_unstemmed Correlation of Standardized Uptake Value and Apparent Diffusion Coefficient in Integrated Whole-Body PET/MRI of Primary and Recurrent Cervical Cancer
title_short Correlation of Standardized Uptake Value and Apparent Diffusion Coefficient in Integrated Whole-Body PET/MRI of Primary and Recurrent Cervical Cancer
title_sort correlation of standardized uptake value and apparent diffusion coefficient in integrated whole-body pet/mri of primary and recurrent cervical cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013042/
https://www.ncbi.nlm.nih.gov/pubmed/24804676
http://dx.doi.org/10.1371/journal.pone.0096751
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