Synthesis, Characterization, In Vitro Cytotoxicity, and Apoptosis-Inducing Properties of Ruthenium(II) Complexes

Two new Ru(II) complexes, [Ru(bpy)(2)(FAMP)](ClO(4))(2) 1 and 2, are synthesized and characterized by elemental analysis, electrospray mass spectrometry, and (1)H nuclear magnetic resonance. The in vitro cytotoxicities and apoptosis-inducing properties of these complexes are extensively studied. Com...

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Detalles Bibliográficos
Autores principales: Xu, Li, Zhong, Nan-Jing, Xie, Yang-Yin, Huang, Hong-Liang, Jiang, Guang-Bin, Liu, Yun-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013043/
https://www.ncbi.nlm.nih.gov/pubmed/24804832
http://dx.doi.org/10.1371/journal.pone.0096082
Descripción
Sumario:Two new Ru(II) complexes, [Ru(bpy)(2)(FAMP)](ClO(4))(2) 1 and 2, are synthesized and characterized by elemental analysis, electrospray mass spectrometry, and (1)H nuclear magnetic resonance. The in vitro cytotoxicities and apoptosis-inducing properties of these complexes are extensively studied. Complexes 1 and 2 exhibit potent antiproliferative activities against a panel of human cancer cell lines. The cell cycle analysis shows that complexes 1 and 2 exhibit effective cell growth inhibition by triggering G0/G1 phase arrest and inducing apoptosis by mitochondrial dysfunction. The in vitro DNA binding properties of the two complexes are investigated by different spectrophotometric methods and viscosity measurements.

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