Synthesis, Characterization, In Vitro Cytotoxicity, and Apoptosis-Inducing Properties of Ruthenium(II) Complexes

Two new Ru(II) complexes, [Ru(bpy)(2)(FAMP)](ClO(4))(2) 1 and 2, are synthesized and characterized by elemental analysis, electrospray mass spectrometry, and (1)H nuclear magnetic resonance. The in vitro cytotoxicities and apoptosis-inducing properties of these complexes are extensively studied. Com...

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Autores principales: Xu, Li, Zhong, Nan-Jing, Xie, Yang-Yin, Huang, Hong-Liang, Jiang, Guang-Bin, Liu, Yun-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013043/
https://www.ncbi.nlm.nih.gov/pubmed/24804832
http://dx.doi.org/10.1371/journal.pone.0096082
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author Xu, Li
Zhong, Nan-Jing
Xie, Yang-Yin
Huang, Hong-Liang
Jiang, Guang-Bin
Liu, Yun-Jun
author_facet Xu, Li
Zhong, Nan-Jing
Xie, Yang-Yin
Huang, Hong-Liang
Jiang, Guang-Bin
Liu, Yun-Jun
author_sort Xu, Li
collection PubMed
description Two new Ru(II) complexes, [Ru(bpy)(2)(FAMP)](ClO(4))(2) 1 and 2, are synthesized and characterized by elemental analysis, electrospray mass spectrometry, and (1)H nuclear magnetic resonance. The in vitro cytotoxicities and apoptosis-inducing properties of these complexes are extensively studied. Complexes 1 and 2 exhibit potent antiproliferative activities against a panel of human cancer cell lines. The cell cycle analysis shows that complexes 1 and 2 exhibit effective cell growth inhibition by triggering G0/G1 phase arrest and inducing apoptosis by mitochondrial dysfunction. The in vitro DNA binding properties of the two complexes are investigated by different spectrophotometric methods and viscosity measurements.
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spelling pubmed-40130432014-05-09 Synthesis, Characterization, In Vitro Cytotoxicity, and Apoptosis-Inducing Properties of Ruthenium(II) Complexes Xu, Li Zhong, Nan-Jing Xie, Yang-Yin Huang, Hong-Liang Jiang, Guang-Bin Liu, Yun-Jun PLoS One Research Article Two new Ru(II) complexes, [Ru(bpy)(2)(FAMP)](ClO(4))(2) 1 and 2, are synthesized and characterized by elemental analysis, electrospray mass spectrometry, and (1)H nuclear magnetic resonance. The in vitro cytotoxicities and apoptosis-inducing properties of these complexes are extensively studied. Complexes 1 and 2 exhibit potent antiproliferative activities against a panel of human cancer cell lines. The cell cycle analysis shows that complexes 1 and 2 exhibit effective cell growth inhibition by triggering G0/G1 phase arrest and inducing apoptosis by mitochondrial dysfunction. The in vitro DNA binding properties of the two complexes are investigated by different spectrophotometric methods and viscosity measurements. Public Library of Science 2014-05-07 /pmc/articles/PMC4013043/ /pubmed/24804832 http://dx.doi.org/10.1371/journal.pone.0096082 Text en © 2014 Xu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Xu, Li
Zhong, Nan-Jing
Xie, Yang-Yin
Huang, Hong-Liang
Jiang, Guang-Bin
Liu, Yun-Jun
Synthesis, Characterization, In Vitro Cytotoxicity, and Apoptosis-Inducing Properties of Ruthenium(II) Complexes
title Synthesis, Characterization, In Vitro Cytotoxicity, and Apoptosis-Inducing Properties of Ruthenium(II) Complexes
title_full Synthesis, Characterization, In Vitro Cytotoxicity, and Apoptosis-Inducing Properties of Ruthenium(II) Complexes
title_fullStr Synthesis, Characterization, In Vitro Cytotoxicity, and Apoptosis-Inducing Properties of Ruthenium(II) Complexes
title_full_unstemmed Synthesis, Characterization, In Vitro Cytotoxicity, and Apoptosis-Inducing Properties of Ruthenium(II) Complexes
title_short Synthesis, Characterization, In Vitro Cytotoxicity, and Apoptosis-Inducing Properties of Ruthenium(II) Complexes
title_sort synthesis, characterization, in vitro cytotoxicity, and apoptosis-inducing properties of ruthenium(ii) complexes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013043/
https://www.ncbi.nlm.nih.gov/pubmed/24804832
http://dx.doi.org/10.1371/journal.pone.0096082
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