Identification of Selective Small Molecule Inhibitors of the Nucleotide-Binding Oligomerization Domain 1 (NOD1) Signaling Pathway

NOD1 is an intracellular pattern recognition receptor that recognizes diaminopimelic acid (DAP), a peptidoglycan component in gram negative bacteria. Upon ligand binding, NOD1 assembles with receptor-interacting protein (RIP)-2 kinase and initiates a signaling cascade leading to the production of pr...

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Detalles Bibliográficos
Autores principales: Rickard, David J., Sehon, Clark A., Kasparcova, Viera, Kallal, Lorena A., Haile, Pamela A., Zeng, Xin, Montoute, Monica N., Poore, Derek D., Li, Hu, Wu, Zining, Eidam, Patrick M., Emery, John G., Marquis, Robert W., Gough, Peter J., Bertin, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013053/
https://www.ncbi.nlm.nih.gov/pubmed/24806487
http://dx.doi.org/10.1371/journal.pone.0096737

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013053/
https://www.ncbi.nlm.nih.gov/pubmed/24806487
http://dx.doi.org/10.1371/journal.pone.0096737

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