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Geographical distribution, a risk factor for the incidence of lupus nephritis in China

BACKGROUND: Geographical variation in lupus nephritis epidemiology may indicate important environmental factors contributions to the etiology of lupus nephritis. This paper first describes the epidemiology of biopsy-proven lupus nephritis in China by performing a systematic literature review and the...

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Autores principales: Pan, Qingjun, Li, Yaning, Ye, Ling, Deng, Zhenzhen, Li, Lu, Feng, Yongmin, Liu, Weijing, Liu, Huafeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013059/
https://www.ncbi.nlm.nih.gov/pubmed/24885458
http://dx.doi.org/10.1186/1471-2369-15-67
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author Pan, Qingjun
Li, Yaning
Ye, Ling
Deng, Zhenzhen
Li, Lu
Feng, Yongmin
Liu, Weijing
Liu, Huafeng
author_facet Pan, Qingjun
Li, Yaning
Ye, Ling
Deng, Zhenzhen
Li, Lu
Feng, Yongmin
Liu, Weijing
Liu, Huafeng
author_sort Pan, Qingjun
collection PubMed
description BACKGROUND: Geographical variation in lupus nephritis epidemiology may indicate important environmental factors contributions to the etiology of lupus nephritis. This paper first describes the epidemiology of biopsy-proven lupus nephritis in China by performing a systematic literature review and the possible social-environmental influential factors. METHODS: The keywords “lupus nephritis”, “renal biopsy” and “systemic lupus erythematous” were searched in the three largest Chinese electronic databases and Medline/PubMed. The data of the patients with biopsy-proven lupus nephritis were extracted. The possible environmental influential factors including the population density, ethnic group populations, the ratio of females to males, the average sunshine per year, annual average temperature and annual relative humidity, in different regions of China were analyzed. RESULTS: Forty-one study centers with 34574 renal disease patients, and 3699 lupus nephritis patients met the inclusion criteria. Lupus nephritis accounts for 2.37% to 25% of all renal disease and 27.2% to 80.65% of renal disease associated with secondary glomerular diseases. The male-to-female ratio is approximately 1:5 in lupus nephritis patients. The included period is predominantly from 1995 to 2010. The proportion ratio of biopsy-proven lupus nephritis in all renal disease or in secondary glomerular disease significantly increased with decreasing latitude from the north to the south part of China. The population is predominantly Han Chinese. CONCLUSIONS: Geographical distribution appears to be a risk factor for the incidence of biopsy-proven LN in China.
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spelling pubmed-40130592014-05-08 Geographical distribution, a risk factor for the incidence of lupus nephritis in China Pan, Qingjun Li, Yaning Ye, Ling Deng, Zhenzhen Li, Lu Feng, Yongmin Liu, Weijing Liu, Huafeng BMC Nephrol Research Article BACKGROUND: Geographical variation in lupus nephritis epidemiology may indicate important environmental factors contributions to the etiology of lupus nephritis. This paper first describes the epidemiology of biopsy-proven lupus nephritis in China by performing a systematic literature review and the possible social-environmental influential factors. METHODS: The keywords “lupus nephritis”, “renal biopsy” and “systemic lupus erythematous” were searched in the three largest Chinese electronic databases and Medline/PubMed. The data of the patients with biopsy-proven lupus nephritis were extracted. The possible environmental influential factors including the population density, ethnic group populations, the ratio of females to males, the average sunshine per year, annual average temperature and annual relative humidity, in different regions of China were analyzed. RESULTS: Forty-one study centers with 34574 renal disease patients, and 3699 lupus nephritis patients met the inclusion criteria. Lupus nephritis accounts for 2.37% to 25% of all renal disease and 27.2% to 80.65% of renal disease associated with secondary glomerular diseases. The male-to-female ratio is approximately 1:5 in lupus nephritis patients. The included period is predominantly from 1995 to 2010. The proportion ratio of biopsy-proven lupus nephritis in all renal disease or in secondary glomerular disease significantly increased with decreasing latitude from the north to the south part of China. The population is predominantly Han Chinese. CONCLUSIONS: Geographical distribution appears to be a risk factor for the incidence of biopsy-proven LN in China. BioMed Central 2014-05-01 /pmc/articles/PMC4013059/ /pubmed/24885458 http://dx.doi.org/10.1186/1471-2369-15-67 Text en Copyright © 2014 Pan et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Pan, Qingjun
Li, Yaning
Ye, Ling
Deng, Zhenzhen
Li, Lu
Feng, Yongmin
Liu, Weijing
Liu, Huafeng
Geographical distribution, a risk factor for the incidence of lupus nephritis in China
title Geographical distribution, a risk factor for the incidence of lupus nephritis in China
title_full Geographical distribution, a risk factor for the incidence of lupus nephritis in China
title_fullStr Geographical distribution, a risk factor for the incidence of lupus nephritis in China
title_full_unstemmed Geographical distribution, a risk factor for the incidence of lupus nephritis in China
title_short Geographical distribution, a risk factor for the incidence of lupus nephritis in China
title_sort geographical distribution, a risk factor for the incidence of lupus nephritis in china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013059/
https://www.ncbi.nlm.nih.gov/pubmed/24885458
http://dx.doi.org/10.1186/1471-2369-15-67
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