Cargando…

Imbalanced Protein Expression Patterns of Anabolic, Catabolic, Anti-Catabolic and Inflammatory Cytokines in Degenerative Cervical Disc Cells: New Indications for Gene Therapeutic Treatments of Cervical Disc Diseases

Degenerative disc disease (DDD) of the cervical spine is common after middle age and can cause loss of disc height with painful nerve impingement, bone and joint inflammation. Despite the clinical importance of these problems, in current publications the pathology of cervical disc degeneration has b...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mern, Demissew S., Beierfuß, Anja, Fontana, Johann, Thomé, Claudius, Hegewald, Aldemar A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013068/ https://www.ncbi.nlm.nih.gov/pubmed/24804684 http://dx.doi.org/10.1371/journal.pone.0096870

Ejemplares similares

A Combinatorial Relative Mass Value Evaluation of Endogenous Bioactive Proteins in Three-Dimensional Cultured Nucleus Pulposus Cells of Herniated Intervertebral Discs: Identification of Potential Target Proteins for Gene Therapeutic Approaches
por: Mern, Demissew S., et al.
Publicado: (2013)

APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix
por: Beierfuß, Anja, et al.
Publicado: (2019)

Correction: Imbalanced Protein Expression Patterns of Anabolic, Catabolic, Anti-Catabolic and Inflammatory Cytokines in Degenerative Cervical Disc Cells: New Indications for Gene Therapeutic Treatments of Cervical Disc Diseases
Publicado: (2014)

Knockout of Apolipoprotein E in rabbit promotes premature intervertebral disc degeneration: A new in vivo model for therapeutic approaches of spinal disc disorders
por: Beierfuß, Anja, et al.
Publicado: (2017)

Identification and characterization of human nucleus pulposus cell specific serotypes of adeno-associated virus for gene therapeutic approaches of intervertebral disc disorders
por: Mern, Demissew S., et al.
Publicado: (2015)

Self-complementary adeno-associated virus serotype 6 mediated knockdown of ADAMTS4 induces long-term and effective enhancement of aggrecan in degenerative human nucleus pulposus cells: A new therapeutic approach for intervertebral disc disorders
por: Shenegelegn Mern, Demissew, et al.
Publicado: (2017)

Regenerative and Immunogenic Characteristics of Cultured Nucleus Pulposus Cells from Human Cervical Intervertebral Discs
por: Stich, Stefan, et al.
Publicado: (2015)

The Use of Anabolic Agents in Catabolic States
por: Demling, Robert
Publicado: (2007)

Heme oxygenase-1 attenuates IL-1β induced alteration of anabolic and catabolic activities in intervertebral disc degeneration
por: Hu, Bo, et al.
Publicado: (2016)

Effects of initial boost with TGF-beta 1 and grade of intervertebral disc degeneration on 3D culture of human annulus fibrosus cells
por: Hegewald, Aldemar Andres, et al.
Publicado: (2014)

Epigenetic Regulation of Chondrocyte Catabolism and Anabolism in Osteoarthritis
por: Kim, Hyeonkyeong, et al.
Publicado: (2015)

Vibration paradox in orthodontics: Anabolic and catabolic effects
por: Alikhani, Mani, et al.
Publicado: (2018)

Coupled catabolism and anabolism in autocatalytic RNA sets
por: Arsène, Simon, et al.
Publicado: (2018)

Comparison of posterior foraminotomy and anterior foraminotomy with fusion for treating spondylotic foraminal stenosis of the cervical spine: study protocol for a randomized controlled trial (ForaC)
por: Tschugg, Anja, et al.
Publicado: (2014)

Cervical nucleoplasty as an effective treatment method of cervical degenerative disc disease
por: Jung, Yoo Sun, et al.
Publicado: (2013)

The Role of Anabolic Hormones for Wound Healing in Catabolic States
por: Demling, Robert H.
Publicado: (2005)

A comparison of anterior cervical discectomy and fusion combined with cervical disc arthroplasty and cervical disc arthroplasty for the treatment of skip-level cervical degenerative disc disease: A retrospective study
por: Wu, Ting-kui, et al.
Publicado: (2017)

Indirect meta-analysis comparing clinical outcomes of total cervical disc replacements with fusions for cervical degenerative disc disease
por: Xu, Bin, et al.
Publicado: (2017)

Cervical Disc Arthroplasty for the Treatment of Noncontiguous Cervical Degenerative Disc Disease: Results of Mid‐ to Long‐Term Follow‐up
por: Wu, Ting‐kui, et al.
Publicado: (2023)

Airway microbiota signals anabolic and catabolic remodeling in the transplanted lung
por: Mouraux, Stéphane, et al.
Publicado: (2018)

P2Y Receptors in Bone - Anabolic, Catabolic, or Both?
por: Zhou, Yuhan, et al.
Publicado: (2022)

Histological Changes of Cervical Disc Tissue in Patients with Degenerative Ossification
por: Xiong, Yang, et al.
Publicado: (2022)

Depression and anxiety in cervical degenerative disc disease: Who are susceptible?
por: Sang, Dacheng, et al.
Publicado: (2023)

Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration
por: Millward-Sadler, S Jane, et al.
Publicado: (2009)

A prospective multicenter phase I/II clinical trial to evaluate safety and efficacy of NOVOCART Disc plus autologous disc chondrocyte transplantation in the treatment of nucleotomized and degenerative lumbar disc to avoid secondary disease: study protocol for a randomized controlled trial
por: Tschugg, Anja, et al.
Publicado: (2016)

Catabolic cytokine expression in degenerate and herniated human intervertebral discs: IL-1β and TNFα expression profile
por: Le Maitre, Christine Lyn, et al.
Publicado: (2007)

Anabolic and catabolic responses of human articular chondrocytes to varying oxygen percentages
por: Ströbel, Simon, et al.
Publicado: (2010)

Higher serum phosphorus is associated with catabolic/anabolic imbalance in heart failure
por: Rozentryt, Piotr, et al.
Publicado: (2015)

RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes
por: McDermott, B.T., et al.
Publicado: (2016)

Pharmacological inhibition of tumor anabolism and host catabolism as a cancer therapy
por: Schcolnik-Cabrera, Alejandro, et al.
Publicado: (2021)

Biomechanical comparison of noncontiguous cervical disc arthroplasty and noncontiguous cervical discectomy and fusion in the treatment of noncontinuous cervical degenerative disc disease: a finite element analysis
por: Sun, Xiangyao, et al.
Publicado: (2020)

Anxiety and depression affect pain drawings in cervical degenerative disc disease
por: MacDowall, Anna, et al.
Publicado: (2017)

Postoperative Urinary Retention Following Anterior Cervical Spine Surgery for Degenerative Cervical Disc Diseases
por: Jung, Hyun Ju, et al.
Publicado: (2013)

Clinical presentation and outcome after anterior cervical discectomy and fusion for degenerative cervical disc disease
por: Srikhande, Ninad N, et al.
Publicado: (2019)

Cervical disc arthroplasty with Prestige-LP for the treatment of contiguous 2-level cervical degenerative disc disease: 5-year follow-up results
por: Gao, Xinlin, et al.
Publicado: (2018)

Comparison of discover cervical disc arthroplasty and anterior cervical discectomy and fusion for the treatment of cervical degenerative disc diseases: A meta-analysis of prospective, randomized controlled trials
por: Wang, Ziqi, et al.
Publicado: (2023)

Gene expression of catabolic inflammatory cytokines peak before anabolic inflammatory cytokines after ACL injury in a preclinical model
por: Haslauer, Carla M, et al.
Publicado: (2014)

Oestrogen and Vibration Improve Intervertebral Disc Cell Viability and Decrease Catabolism in Bovine Organ Cultures
por: Widmayer, Franziska, et al.
Publicado: (2023)

Effects of hypoxia on anabolic and catabolic gene expression and DNA methylation in OA chondrocytes
por: Alvarez, Karl, et al.
Publicado: (2014)

Integration of flux measurements to resolve changes in anabolic and catabolic metabolism in cardiac myocytes
por: Gibb, Andrew A., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_j0a5q50cedpt3gpjqiskh50dsn