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Alveolar epithelial cells undergo epithelial-mesenchymal transition in acute interstitial pneumonia: a case report

BACKGROUND: Acute interstitial pneumonia is a rare interstitial lung disease that rapidly progresses to respiratory failure or death. Several studies showed that myofibroblast plays an important role in the evolution of diffuse alveolar damage, which is the typical feature of acute interstitial pneu...

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Autores principales: Li, Hongbo, Zhang, Jinjin, Song, Xiaodong, Wang, Tao, Li, Zhi, Hao, Dong, Wang, Xiaozhi, Zheng, Qingyin, Mao, Cuiping, Xu, Pan, Lv, Changjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013083/
https://www.ncbi.nlm.nih.gov/pubmed/24755111
http://dx.doi.org/10.1186/1471-2466-14-67
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author Li, Hongbo
Zhang, Jinjin
Song, Xiaodong
Wang, Tao
Li, Zhi
Hao, Dong
Wang, Xiaozhi
Zheng, Qingyin
Mao, Cuiping
Xu, Pan
Lv, Changjun
author_facet Li, Hongbo
Zhang, Jinjin
Song, Xiaodong
Wang, Tao
Li, Zhi
Hao, Dong
Wang, Xiaozhi
Zheng, Qingyin
Mao, Cuiping
Xu, Pan
Lv, Changjun
author_sort Li, Hongbo
collection PubMed
description BACKGROUND: Acute interstitial pneumonia is a rare interstitial lung disease that rapidly progresses to respiratory failure or death. Several studies showed that myofibroblast plays an important role in the evolution of diffuse alveolar damage, which is the typical feature of acute interstitial pneumonia. However, no evidence exists whether alveolar epithelial cells are an additional source of myofibroblasts via epithelial-mesenchymal transition in acute interstitial pneumonia. CASE PRESENTATION: In this report, we present a case of acute interstitial pneumonia in a previously healthy 28-year-old non-smoking woman. Chest high-resolution computed tomography scan showed bilateral and diffusely ground-glass opacification. The biopsy was performed on the fifth day of her hospitalization, and results showed manifestation of acute exudative phase of diffuse alveolar damage characterized by hyaline membrane formation. On the basis of the preliminary diagnosis of acute interstitial pneumonia, high-dose glucocorticoid was used. However, this drug showed poor clinical response and could improve the patient’s symptoms only during the early phase. The patient eventually died of respiratory dysfunction. Histological findings in autopsy were consistent with the late form of acute interstitial pneumonia. CONCLUSIONS: The results in this study revealed that alveolar epithelial cells underwent epithelial-mesenchymal transition and may be an important origin of myofibroblasts in the progression of acute interstitial pneumonia. Conducting research on the transformation of alveolar epithelial cells into myofibroblasts in the lung tissue of patients with acute interstitial pneumonia may be beneficial for the treatment of this disease. However, to our knowledge, no research has been conducted on this topic.
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spelling pubmed-40130832014-05-08 Alveolar epithelial cells undergo epithelial-mesenchymal transition in acute interstitial pneumonia: a case report Li, Hongbo Zhang, Jinjin Song, Xiaodong Wang, Tao Li, Zhi Hao, Dong Wang, Xiaozhi Zheng, Qingyin Mao, Cuiping Xu, Pan Lv, Changjun BMC Pulm Med Case Report BACKGROUND: Acute interstitial pneumonia is a rare interstitial lung disease that rapidly progresses to respiratory failure or death. Several studies showed that myofibroblast plays an important role in the evolution of diffuse alveolar damage, which is the typical feature of acute interstitial pneumonia. However, no evidence exists whether alveolar epithelial cells are an additional source of myofibroblasts via epithelial-mesenchymal transition in acute interstitial pneumonia. CASE PRESENTATION: In this report, we present a case of acute interstitial pneumonia in a previously healthy 28-year-old non-smoking woman. Chest high-resolution computed tomography scan showed bilateral and diffusely ground-glass opacification. The biopsy was performed on the fifth day of her hospitalization, and results showed manifestation of acute exudative phase of diffuse alveolar damage characterized by hyaline membrane formation. On the basis of the preliminary diagnosis of acute interstitial pneumonia, high-dose glucocorticoid was used. However, this drug showed poor clinical response and could improve the patient’s symptoms only during the early phase. The patient eventually died of respiratory dysfunction. Histological findings in autopsy were consistent with the late form of acute interstitial pneumonia. CONCLUSIONS: The results in this study revealed that alveolar epithelial cells underwent epithelial-mesenchymal transition and may be an important origin of myofibroblasts in the progression of acute interstitial pneumonia. Conducting research on the transformation of alveolar epithelial cells into myofibroblasts in the lung tissue of patients with acute interstitial pneumonia may be beneficial for the treatment of this disease. However, to our knowledge, no research has been conducted on this topic. BioMed Central 2014-04-23 /pmc/articles/PMC4013083/ /pubmed/24755111 http://dx.doi.org/10.1186/1471-2466-14-67 Text en Copyright © 2014 Li et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Li, Hongbo
Zhang, Jinjin
Song, Xiaodong
Wang, Tao
Li, Zhi
Hao, Dong
Wang, Xiaozhi
Zheng, Qingyin
Mao, Cuiping
Xu, Pan
Lv, Changjun
Alveolar epithelial cells undergo epithelial-mesenchymal transition in acute interstitial pneumonia: a case report
title Alveolar epithelial cells undergo epithelial-mesenchymal transition in acute interstitial pneumonia: a case report
title_full Alveolar epithelial cells undergo epithelial-mesenchymal transition in acute interstitial pneumonia: a case report
title_fullStr Alveolar epithelial cells undergo epithelial-mesenchymal transition in acute interstitial pneumonia: a case report
title_full_unstemmed Alveolar epithelial cells undergo epithelial-mesenchymal transition in acute interstitial pneumonia: a case report
title_short Alveolar epithelial cells undergo epithelial-mesenchymal transition in acute interstitial pneumonia: a case report
title_sort alveolar epithelial cells undergo epithelial-mesenchymal transition in acute interstitial pneumonia: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013083/
https://www.ncbi.nlm.nih.gov/pubmed/24755111
http://dx.doi.org/10.1186/1471-2466-14-67
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