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Metabolic Syndrome and Chronic Kidney Disease in an Adult Korean Population: Results from the Korean National Health Screening

BACKGROUND: This study was aimed to examine the prevalence of metabolic syndrome (MS) and chronic kidney disease (CKD), and the association between MS and its components with CKD in Korea. METHODS: We excluded diabetes to appreciate the real impact of MS and performed a cross-sectional study using t...

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Autores principales: Kang, Yong Un, Kim, Ha Yeon, Choi, Joon Seok, Kim, Chang Seong, Bae, Eun Hui, Ma, Seong Kwon, Kim, Soo Wan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013132/
https://www.ncbi.nlm.nih.gov/pubmed/24807226
http://dx.doi.org/10.1371/journal.pone.0093795
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author Kang, Yong Un
Kim, Ha Yeon
Choi, Joon Seok
Kim, Chang Seong
Bae, Eun Hui
Ma, Seong Kwon
Kim, Soo Wan
author_facet Kang, Yong Un
Kim, Ha Yeon
Choi, Joon Seok
Kim, Chang Seong
Bae, Eun Hui
Ma, Seong Kwon
Kim, Soo Wan
author_sort Kang, Yong Un
collection PubMed
description BACKGROUND: This study was aimed to examine the prevalence of metabolic syndrome (MS) and chronic kidney disease (CKD), and the association between MS and its components with CKD in Korea. METHODS: We excluded diabetes to appreciate the real impact of MS and performed a cross-sectional study using the general health screening data of 10,253,085 (48.86±13.83 years, men 56.18%) participants (age, ≥20 years) from the Korean National Health Screening 2011. CKD was defined as dipstick proteinuria ≥1 or an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m(2). RESULTS: The prevalence of CKD was 6.15% (men, 5.37%; women, 7.15%). Further, 22.25% study population had MS (abdominal obesity, 27.98%; hypertriglyceridemia, 30.09%; low high-density cholesterol levels, 19.74%; high blood pressure, 43.45%; and high fasting glucose levels, 30.44%). Multivariate-adjusted analysis indicated that proteinuria risk increased in participants with MS (odds ratio [OR] 1.884, 95% confidence interval [CI] 1.867–1.902, P<0.001). The presence of MS was associated with eGFR<60 mL/min/1.73 m(2) (OR 1.364, 95% CI 1.355–1.373, P<0.001). MS individual components were also associated with an increased CKD risk. The strength of association between MS and the development of CKD increase as the number of components increased from 1 to 5. In sub-analysis by men and women, MS and its each components were a significant determinant for CKD. CONCLUSIONS: MS and its individual components can predict the risk of prevalent CKD for men and women.
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spelling pubmed-40131322014-05-09 Metabolic Syndrome and Chronic Kidney Disease in an Adult Korean Population: Results from the Korean National Health Screening Kang, Yong Un Kim, Ha Yeon Choi, Joon Seok Kim, Chang Seong Bae, Eun Hui Ma, Seong Kwon Kim, Soo Wan PLoS One Research Article BACKGROUND: This study was aimed to examine the prevalence of metabolic syndrome (MS) and chronic kidney disease (CKD), and the association between MS and its components with CKD in Korea. METHODS: We excluded diabetes to appreciate the real impact of MS and performed a cross-sectional study using the general health screening data of 10,253,085 (48.86±13.83 years, men 56.18%) participants (age, ≥20 years) from the Korean National Health Screening 2011. CKD was defined as dipstick proteinuria ≥1 or an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m(2). RESULTS: The prevalence of CKD was 6.15% (men, 5.37%; women, 7.15%). Further, 22.25% study population had MS (abdominal obesity, 27.98%; hypertriglyceridemia, 30.09%; low high-density cholesterol levels, 19.74%; high blood pressure, 43.45%; and high fasting glucose levels, 30.44%). Multivariate-adjusted analysis indicated that proteinuria risk increased in participants with MS (odds ratio [OR] 1.884, 95% confidence interval [CI] 1.867–1.902, P<0.001). The presence of MS was associated with eGFR<60 mL/min/1.73 m(2) (OR 1.364, 95% CI 1.355–1.373, P<0.001). MS individual components were also associated with an increased CKD risk. The strength of association between MS and the development of CKD increase as the number of components increased from 1 to 5. In sub-analysis by men and women, MS and its each components were a significant determinant for CKD. CONCLUSIONS: MS and its individual components can predict the risk of prevalent CKD for men and women. Public Library of Science 2014-05-07 /pmc/articles/PMC4013132/ /pubmed/24807226 http://dx.doi.org/10.1371/journal.pone.0093795 Text en © 2014 Kang et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kang, Yong Un
Kim, Ha Yeon
Choi, Joon Seok
Kim, Chang Seong
Bae, Eun Hui
Ma, Seong Kwon
Kim, Soo Wan
Metabolic Syndrome and Chronic Kidney Disease in an Adult Korean Population: Results from the Korean National Health Screening
title Metabolic Syndrome and Chronic Kidney Disease in an Adult Korean Population: Results from the Korean National Health Screening
title_full Metabolic Syndrome and Chronic Kidney Disease in an Adult Korean Population: Results from the Korean National Health Screening
title_fullStr Metabolic Syndrome and Chronic Kidney Disease in an Adult Korean Population: Results from the Korean National Health Screening
title_full_unstemmed Metabolic Syndrome and Chronic Kidney Disease in an Adult Korean Population: Results from the Korean National Health Screening
title_short Metabolic Syndrome and Chronic Kidney Disease in an Adult Korean Population: Results from the Korean National Health Screening
title_sort metabolic syndrome and chronic kidney disease in an adult korean population: results from the korean national health screening
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013132/
https://www.ncbi.nlm.nih.gov/pubmed/24807226
http://dx.doi.org/10.1371/journal.pone.0093795
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