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The prevalence and prevention of nasopharyngeal carcinoma in China
Nasopharyngeal carcinoma (NPC) has remarkable epidemiological features, including regional, racial, and familial aggregations. The aim of this review is to describe the epidemiological characteristics of NPC and to propose possible causes for the high incidence patterns in southern China. Since the...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Sun Yat-sen University Cancer Center
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013340/ https://www.ncbi.nlm.nih.gov/pubmed/21272443 http://dx.doi.org/10.5732/cjc.010.10377 |
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author | Cao, Su-Mei Simons, Malcolm J. Qian, Chao-Nan |
author_facet | Cao, Su-Mei Simons, Malcolm J. Qian, Chao-Nan |
author_sort | Cao, Su-Mei |
collection | PubMed |
description | Nasopharyngeal carcinoma (NPC) has remarkable epidemiological features, including regional, racial, and familial aggregations. The aim of this review is to describe the epidemiological characteristics of NPC and to propose possible causes for the high incidence patterns in southern China. Since the etiology of NPC is not completely understood, approaches to primary prevention of NPC remain under consideration. This situation highlights the need to conduct secondary prevention, including improving rates of early detection, early diagnosis, and early treatment in NPC patients. Since the 1970's, high-risk populations in southern China have been screened extensively for early detection of NPC using anti–Epstein-Barr virus (EBV) serum biomarkers. This review summarizes several large screening studies that have been conducted in the high-incidence areas of China. Screening markers, high-risk age range for screening, time intervals for blood re-examination, and the effectiveness of these screening studies will be discussed. Conduction of prospective randomized controlled screening trials in southern China can be expected to maximize the cost-effectiveness of early NPC detection screening. |
format | Online Article Text |
id | pubmed-4013340 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Sun Yat-sen University Cancer Center |
record_format | MEDLINE/PubMed |
spelling | pubmed-40133402014-05-15 The prevalence and prevention of nasopharyngeal carcinoma in China Cao, Su-Mei Simons, Malcolm J. Qian, Chao-Nan Chin J Cancer Focused Feature: NPC epidemiology and genetics Nasopharyngeal carcinoma (NPC) has remarkable epidemiological features, including regional, racial, and familial aggregations. The aim of this review is to describe the epidemiological characteristics of NPC and to propose possible causes for the high incidence patterns in southern China. Since the etiology of NPC is not completely understood, approaches to primary prevention of NPC remain under consideration. This situation highlights the need to conduct secondary prevention, including improving rates of early detection, early diagnosis, and early treatment in NPC patients. Since the 1970's, high-risk populations in southern China have been screened extensively for early detection of NPC using anti–Epstein-Barr virus (EBV) serum biomarkers. This review summarizes several large screening studies that have been conducted in the high-incidence areas of China. Screening markers, high-risk age range for screening, time intervals for blood re-examination, and the effectiveness of these screening studies will be discussed. Conduction of prospective randomized controlled screening trials in southern China can be expected to maximize the cost-effectiveness of early NPC detection screening. Sun Yat-sen University Cancer Center 2011-02 /pmc/articles/PMC4013340/ /pubmed/21272443 http://dx.doi.org/10.5732/cjc.010.10377 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission. |
spellingShingle | Focused Feature: NPC epidemiology and genetics Cao, Su-Mei Simons, Malcolm J. Qian, Chao-Nan The prevalence and prevention of nasopharyngeal carcinoma in China |
title | The prevalence and prevention of nasopharyngeal carcinoma in China |
title_full | The prevalence and prevention of nasopharyngeal carcinoma in China |
title_fullStr | The prevalence and prevention of nasopharyngeal carcinoma in China |
title_full_unstemmed | The prevalence and prevention of nasopharyngeal carcinoma in China |
title_short | The prevalence and prevention of nasopharyngeal carcinoma in China |
title_sort | prevalence and prevention of nasopharyngeal carcinoma in china |
topic | Focused Feature: NPC epidemiology and genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013340/ https://www.ncbi.nlm.nih.gov/pubmed/21272443 http://dx.doi.org/10.5732/cjc.010.10377 |
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