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MLL1/WDR5 complex in leukemogenesis and epigenetic regulation

MLL1 is a histone H3Lys4 methyltransferase and forms a complex with WDR5 and other components. It plays important roles in developmental events, transcriptional regulation, and leukemogenesis. MLL1 -fusion proteins resulting from chromosomal translocations are molecular hallmarks of a special type o...

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Detalles Bibliográficos
Autores principales: Wu, Min, Shu, Hong-Bing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sun Yat-sen University Cancer Center 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013350/
https://www.ncbi.nlm.nih.gov/pubmed/21439245
http://dx.doi.org/10.5732/cjc.011.10055
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author Wu, Min
Shu, Hong-Bing
author_facet Wu, Min
Shu, Hong-Bing
author_sort Wu, Min
collection PubMed
description MLL1 is a histone H3Lys4 methyltransferase and forms a complex with WDR5 and other components. It plays important roles in developmental events, transcriptional regulation, and leukemogenesis. MLL1 -fusion proteins resulting from chromosomal translocations are molecular hallmarks of a special type of leukemia, which occurs in over 70% infant leukemia patients and often accompanies poor prognosis. Investigations in the past years on leukemogenesis and the MLL1-WDR5 histone H3Lys4 methyltransferase complex demonstrate that epigenetic regulation is one of the key steps in development and human diseases.
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spelling pubmed-40133502014-05-15 MLL1/WDR5 complex in leukemogenesis and epigenetic regulation Wu, Min Shu, Hong-Bing Chin J Cancer Review MLL1 is a histone H3Lys4 methyltransferase and forms a complex with WDR5 and other components. It plays important roles in developmental events, transcriptional regulation, and leukemogenesis. MLL1 -fusion proteins resulting from chromosomal translocations are molecular hallmarks of a special type of leukemia, which occurs in over 70% infant leukemia patients and often accompanies poor prognosis. Investigations in the past years on leukemogenesis and the MLL1-WDR5 histone H3Lys4 methyltransferase complex demonstrate that epigenetic regulation is one of the key steps in development and human diseases. Sun Yat-sen University Cancer Center 2011-04 /pmc/articles/PMC4013350/ /pubmed/21439245 http://dx.doi.org/10.5732/cjc.011.10055 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Review
Wu, Min
Shu, Hong-Bing
MLL1/WDR5 complex in leukemogenesis and epigenetic regulation
title MLL1/WDR5 complex in leukemogenesis and epigenetic regulation
title_full MLL1/WDR5 complex in leukemogenesis and epigenetic regulation
title_fullStr MLL1/WDR5 complex in leukemogenesis and epigenetic regulation
title_full_unstemmed MLL1/WDR5 complex in leukemogenesis and epigenetic regulation
title_short MLL1/WDR5 complex in leukemogenesis and epigenetic regulation
title_sort mll1/wdr5 complex in leukemogenesis and epigenetic regulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013350/
https://www.ncbi.nlm.nih.gov/pubmed/21439245
http://dx.doi.org/10.5732/cjc.011.10055
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