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Single-nucleotide polymorphisms among microRNA: big effects on cancer

MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the transcriptional or posttranscriptional level. Many miRNAs are found to play a significant role in cancer development either as tumor suppressor genes or as oncogenes. Examination of tumor-specific miRNA expression prof...

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Detalles Bibliográficos
Autores principales: Song, Feng-Ju, Chen, Ke-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sun Yat-sen University Cancer Center 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013412/
https://www.ncbi.nlm.nih.gov/pubmed/21627860
http://dx.doi.org/10.5732/cjc.011.10142
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author Song, Feng-Ju
Chen, Ke-Xin
author_facet Song, Feng-Ju
Chen, Ke-Xin
author_sort Song, Feng-Ju
collection PubMed
description MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the transcriptional or posttranscriptional level. Many miRNAs are found to play a significant role in cancer development either as tumor suppressor genes or as oncogenes. Examination of tumor-specific miRNA expression profiles in diverse cancers has revealed widespread deregulation of these molecules, whose loss and overexpression respectively have diagnostic and prognostic significance. Genetic variations, mostly single-nucleotide polymorphisms (SNPs) within miRNA sequences or their target sites, have been found to be associated with many kinds of cancers. In this review, we summarize the current knowledge of miRNAs including their biogenesis and role in cancer development, and finally, how SNPs among miRNAs affect miRNA biogenesis and contribute to cancer.
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spelling pubmed-40134122014-05-15 Single-nucleotide polymorphisms among microRNA: big effects on cancer Song, Feng-Ju Chen, Ke-Xin Chin J Cancer Review MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the transcriptional or posttranscriptional level. Many miRNAs are found to play a significant role in cancer development either as tumor suppressor genes or as oncogenes. Examination of tumor-specific miRNA expression profiles in diverse cancers has revealed widespread deregulation of these molecules, whose loss and overexpression respectively have diagnostic and prognostic significance. Genetic variations, mostly single-nucleotide polymorphisms (SNPs) within miRNA sequences or their target sites, have been found to be associated with many kinds of cancers. In this review, we summarize the current knowledge of miRNAs including their biogenesis and role in cancer development, and finally, how SNPs among miRNAs affect miRNA biogenesis and contribute to cancer. Sun Yat-sen University Cancer Center 2011-06 /pmc/articles/PMC4013412/ /pubmed/21627860 http://dx.doi.org/10.5732/cjc.011.10142 Text en Chinese Journal of Cancer http://creativecommons.org/licenses/by-nc-sa/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License, which allows readers to alter, transform, or build upon the article and then distribute the resulting work under the same or similar license to this one. The work must be attributed back to the original author and commercial use is not permitted without specific permission.
spellingShingle Review
Song, Feng-Ju
Chen, Ke-Xin
Single-nucleotide polymorphisms among microRNA: big effects on cancer
title Single-nucleotide polymorphisms among microRNA: big effects on cancer
title_full Single-nucleotide polymorphisms among microRNA: big effects on cancer
title_fullStr Single-nucleotide polymorphisms among microRNA: big effects on cancer
title_full_unstemmed Single-nucleotide polymorphisms among microRNA: big effects on cancer
title_short Single-nucleotide polymorphisms among microRNA: big effects on cancer
title_sort single-nucleotide polymorphisms among microrna: big effects on cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013412/
https://www.ncbi.nlm.nih.gov/pubmed/21627860
http://dx.doi.org/10.5732/cjc.011.10142
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