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Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature

PURPOSE: To present the clinical, imaging, pathological and immunohistochemical features of giant cell angiofibroma (GCA). CASE PRESENTATION: In this paper we report an atypical case of a GCA extending from the parotid to the parapharyngeal space. The lesion was being treated as a vascular malformat...

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Autores principales: He, Yue, Zhang, Chenping, Liu, Guanglong, Tian, Zhuowei, Wang, Lizhen, Kalfarentzos, Evagelos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013432/
https://www.ncbi.nlm.nih.gov/pubmed/24758544
http://dx.doi.org/10.1186/1477-7819-12-117
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author He, Yue
Zhang, Chenping
Liu, Guanglong
Tian, Zhuowei
Wang, Lizhen
Kalfarentzos, Evagelos
author_facet He, Yue
Zhang, Chenping
Liu, Guanglong
Tian, Zhuowei
Wang, Lizhen
Kalfarentzos, Evagelos
author_sort He, Yue
collection PubMed
description PURPOSE: To present the clinical, imaging, pathological and immunohistochemical features of giant cell angiofibroma (GCA). CASE PRESENTATION: In this paper we report an atypical case of a GCA extending from the parotid to the parapharyngeal space. The lesion was being treated as a vascular malformation for one year prior to surgical removal. We summarize the clinical manifestations, imaging, pathological and molecular features of this rare disease. After complete surgical removal of the tumor, immunohistochemical analysis revealed strong positivity for the mesenchymal markers vimentin, CD34, CD31 and CD99 in neoplastic cells. Tumor proliferation antigen marker Ki67 was partly positive (<5% of cells). Tumor cells were negative for muscle-specific actin, epithelial membrane antigen, smooth muscle actin, cytokeratin pan, S100, desmin, glial fibrillary acidic protein, myogenin, MyoD1 and F8. The morphological and immunohistochemical profile was consistent with the diagnosis of GCA. CONCLUSION: GCA is a rare soft tissue tumor that can easily be misdiagnosed in the clinical preoperative setting. In view of the clinical, pathological and molecular features of the tumor, complete surgical removal is the current optimal treatment option, providing accurate diagnosis and low to minimal recurrence rate.
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spelling pubmed-40134322014-05-09 Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature He, Yue Zhang, Chenping Liu, Guanglong Tian, Zhuowei Wang, Lizhen Kalfarentzos, Evagelos World J Surg Oncol Case Report PURPOSE: To present the clinical, imaging, pathological and immunohistochemical features of giant cell angiofibroma (GCA). CASE PRESENTATION: In this paper we report an atypical case of a GCA extending from the parotid to the parapharyngeal space. The lesion was being treated as a vascular malformation for one year prior to surgical removal. We summarize the clinical manifestations, imaging, pathological and molecular features of this rare disease. After complete surgical removal of the tumor, immunohistochemical analysis revealed strong positivity for the mesenchymal markers vimentin, CD34, CD31 and CD99 in neoplastic cells. Tumor proliferation antigen marker Ki67 was partly positive (<5% of cells). Tumor cells were negative for muscle-specific actin, epithelial membrane antigen, smooth muscle actin, cytokeratin pan, S100, desmin, glial fibrillary acidic protein, myogenin, MyoD1 and F8. The morphological and immunohistochemical profile was consistent with the diagnosis of GCA. CONCLUSION: GCA is a rare soft tissue tumor that can easily be misdiagnosed in the clinical preoperative setting. In view of the clinical, pathological and molecular features of the tumor, complete surgical removal is the current optimal treatment option, providing accurate diagnosis and low to minimal recurrence rate. BioMed Central 2014-04-24 /pmc/articles/PMC4013432/ /pubmed/24758544 http://dx.doi.org/10.1186/1477-7819-12-117 Text en Copyright © 2014 He et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
He, Yue
Zhang, Chenping
Liu, Guanglong
Tian, Zhuowei
Wang, Lizhen
Kalfarentzos, Evagelos
Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature
title Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature
title_full Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature
title_fullStr Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature
title_full_unstemmed Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature
title_short Giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature
title_sort giant cell angiofibroma misdiagnosed as a vascular malformation and treated with absolute alcohol for one year: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013432/
https://www.ncbi.nlm.nih.gov/pubmed/24758544
http://dx.doi.org/10.1186/1477-7819-12-117
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