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Generation of the Cdk5 activator p25 is a memory mechanism that is affected in early Alzheimer’s disease

About 15 years ago it was proposed that generation of the truncated protein p25 contributes to toxicity in Alzheimer’s disease (AD). p25 is a calcium-dependent degradation product of p35, the principal activator of cyclin-dependent kinase 5 (Cdk5). The biochemical properties of p25 suggested that it...

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Detalles Bibliográficos
Autor principal:	Giese, K. Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013459/ https://www.ncbi.nlm.nih.gov/pubmed/24822036 http://dx.doi.org/10.3389/fnmol.2014.00036

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