Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation

Oncogene-induced reactive oxygen species (ROS) have been proposed to be signaling molecules that mediate proliferative cues. However, ROS may also cause DNA damage and proliferative arrest. How these apparently opposite roles can be reconciled, especially in the context of oncogene-induced cellular...

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Detalles Bibliográficos
Autores principales: Ogrunc, M, Di Micco, R, Liontos, M, Bombardelli, L, Mione, M, Fumagalli, M, Gorgoulis, V G, d'Adda di Fagagna, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013514/
https://www.ncbi.nlm.nih.gov/pubmed/24583638
http://dx.doi.org/10.1038/cdd.2014.16

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