Dysregulation of Wnt inhibitory factor 1 (Wif1) expression resulted in aberrant Wnt-β-catenin signaling and cell death of the cloaca endoderm, and anorectal malformations

In mammalian urorectal development, the urorectal septum (urs) descends from the ventral body wall to the cloaca membrane (cm) to partition the cloaca into urogenital sinus and rectum. Defective urs growth results in human congenital anorectal malformations (ARMs), and their pathogenic mechanisms ar...

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Detalles Bibliográficos
Autores principales: Ng, R C-L, Matsumaru, D, Ho, A S-H, Garcia-Barceló, M-M, Yuan, Z-W, Smith, D, Kodjabachian, L, Tam, P K-H, Yamada, G, Lui, V C-H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013516/
https://www.ncbi.nlm.nih.gov/pubmed/24632949
http://dx.doi.org/10.1038/cdd.2014.20

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