Cargando…
Isolation, Bioactivity, and Production of ortho-Hydroxydaidzein and ortho-Hydroxygenistein
Daidzein and genistein are two major components of soy isoflavones. They exist abundantly in plants and possess multiple bioactivities. In contrast, ortho-hydroxydaidzein (OHD) and ortho-hydroxygenistein (OHG), including 6-hydroxydaidzein (6-OHD), 8-hydroxydaidzein (8-OHD), 3′-hydroxydaidzein (3′-OH...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013590/ https://www.ncbi.nlm.nih.gov/pubmed/24705463 http://dx.doi.org/10.3390/ijms15045699 |
_version_ | 1782315079633469440 |
---|---|
author | Chang, Te-Sheng |
author_facet | Chang, Te-Sheng |
author_sort | Chang, Te-Sheng |
collection | PubMed |
description | Daidzein and genistein are two major components of soy isoflavones. They exist abundantly in plants and possess multiple bioactivities. In contrast, ortho-hydroxydaidzein (OHD) and ortho-hydroxygenistein (OHG), including 6-hydroxydaidzein (6-OHD), 8-hydroxydaidzein (8-OHD), 3′-hydroxydaidzein (3′-OHD), 6-hydroxygenistein (6-OHG), 8-hydroxygenistein (8-OHG), and 3′-hydroxygenistein (3′-OHG), are rarely found in plants. Instead, they are usually isolated from fermented soybean foods or microbial fermentation broth feeding with soybean meal. Accordingly, the bioactivity of OHD and OHG has been investigated less compared to that of soy isoflavones. Recently, OHD and OHG were produced by genetically engineering microorganisms through gene cloning of cytochrome P450 (CYP) enzyme systems. This success opens up bioactivity investigation and industrial applications of OHD and OHG in the future. This article reviews isolation of OHD and OHG from non-synthetic sources and production of the compounds by genetically modified microorganisms. Several bioactivities, such as anticancer and antimelanogenesis-related activities, of OHD and OHG, are also discussed. |
format | Online Article Text |
id | pubmed-4013590 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-40135902014-05-08 Isolation, Bioactivity, and Production of ortho-Hydroxydaidzein and ortho-Hydroxygenistein Chang, Te-Sheng Int J Mol Sci Review Daidzein and genistein are two major components of soy isoflavones. They exist abundantly in plants and possess multiple bioactivities. In contrast, ortho-hydroxydaidzein (OHD) and ortho-hydroxygenistein (OHG), including 6-hydroxydaidzein (6-OHD), 8-hydroxydaidzein (8-OHD), 3′-hydroxydaidzein (3′-OHD), 6-hydroxygenistein (6-OHG), 8-hydroxygenistein (8-OHG), and 3′-hydroxygenistein (3′-OHG), are rarely found in plants. Instead, they are usually isolated from fermented soybean foods or microbial fermentation broth feeding with soybean meal. Accordingly, the bioactivity of OHD and OHG has been investigated less compared to that of soy isoflavones. Recently, OHD and OHG were produced by genetically engineering microorganisms through gene cloning of cytochrome P450 (CYP) enzyme systems. This success opens up bioactivity investigation and industrial applications of OHD and OHG in the future. This article reviews isolation of OHD and OHG from non-synthetic sources and production of the compounds by genetically modified microorganisms. Several bioactivities, such as anticancer and antimelanogenesis-related activities, of OHD and OHG, are also discussed. Molecular Diversity Preservation International (MDPI) 2014-04-03 /pmc/articles/PMC4013590/ /pubmed/24705463 http://dx.doi.org/10.3390/ijms15045699 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Chang, Te-Sheng Isolation, Bioactivity, and Production of ortho-Hydroxydaidzein and ortho-Hydroxygenistein |
title | Isolation, Bioactivity, and Production of ortho-Hydroxydaidzein and ortho-Hydroxygenistein |
title_full | Isolation, Bioactivity, and Production of ortho-Hydroxydaidzein and ortho-Hydroxygenistein |
title_fullStr | Isolation, Bioactivity, and Production of ortho-Hydroxydaidzein and ortho-Hydroxygenistein |
title_full_unstemmed | Isolation, Bioactivity, and Production of ortho-Hydroxydaidzein and ortho-Hydroxygenistein |
title_short | Isolation, Bioactivity, and Production of ortho-Hydroxydaidzein and ortho-Hydroxygenistein |
title_sort | isolation, bioactivity, and production of ortho-hydroxydaidzein and ortho-hydroxygenistein |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013590/ https://www.ncbi.nlm.nih.gov/pubmed/24705463 http://dx.doi.org/10.3390/ijms15045699 |
work_keys_str_mv | AT changtesheng isolationbioactivityandproductionoforthohydroxydaidzeinandorthohydroxygenistein |