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Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size

Ceria nanoparticles (nano-ceria) have recently gained a wide range of applications, which might pose unwanted risks to both the environment and human health. The greatest potential for the environmental discharge of nano-ceria appears to be in their use as a diesel fuel additive. The present study w...

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Autores principales: Peng, Lu, He, Xiao, Zhang, Peng, Zhang, Jing, Li, Yuanyuan, Zhang, Junzhe, Ma, Yuhui, Ding, Yayun, Wu, Zhenqiang, Chai, Zhifang, Zhang, Zhiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013616/
https://www.ncbi.nlm.nih.gov/pubmed/24727375
http://dx.doi.org/10.3390/ijms15046072
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author Peng, Lu
He, Xiao
Zhang, Peng
Zhang, Jing
Li, Yuanyuan
Zhang, Junzhe
Ma, Yuhui
Ding, Yayun
Wu, Zhenqiang
Chai, Zhifang
Zhang, Zhiyong
author_facet Peng, Lu
He, Xiao
Zhang, Peng
Zhang, Jing
Li, Yuanyuan
Zhang, Junzhe
Ma, Yuhui
Ding, Yayun
Wu, Zhenqiang
Chai, Zhifang
Zhang, Zhiyong
author_sort Peng, Lu
collection PubMed
description Ceria nanoparticles (nano-ceria) have recently gained a wide range of applications, which might pose unwanted risks to both the environment and human health. The greatest potential for the environmental discharge of nano-ceria appears to be in their use as a diesel fuel additive. The present study was designed to explore the pulmonary toxicity of nano-ceria in mice after a single exposure via intratracheal instillation. Two types of nano-ceria with the same distribution of a primary size (3–5 nm), but different redox activity, were used: Ceria-p, synthesized by a precipitation route, and Ceria-h, synthesized by a hydrothermal route. Both Ceria-p and Ceria-h induced oxidative stress, inflammatory responses and cytotoxicity in mice, but their toxicological profiles were quite different. The mean size of Ceria-p agglomerates was much smaller compared to Ceria-h, thereby causing a more potent acute inflammation, due to their higher number concentration of agglomerates and higher deposition rate in the deep lung. Ceria-h had a higher reactivity to catalyzing the generation of reactive oxygen species (ROS), and caused two waves of lung injury: bronchoalveolar lavage (BAL) inflammation and cytotoxicity in the early stage and redox-activity-evoked lipid peroxidation and pro-inflammation in the latter stage. Therefore, the size distribution of ceria-containing agglomerates in the exhaust, as well as their surface chemistry are essential characteristics to assess the potential risks of using nano-ceria as a fuel additive.
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spelling pubmed-40136162014-05-08 Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size Peng, Lu He, Xiao Zhang, Peng Zhang, Jing Li, Yuanyuan Zhang, Junzhe Ma, Yuhui Ding, Yayun Wu, Zhenqiang Chai, Zhifang Zhang, Zhiyong Int J Mol Sci Article Ceria nanoparticles (nano-ceria) have recently gained a wide range of applications, which might pose unwanted risks to both the environment and human health. The greatest potential for the environmental discharge of nano-ceria appears to be in their use as a diesel fuel additive. The present study was designed to explore the pulmonary toxicity of nano-ceria in mice after a single exposure via intratracheal instillation. Two types of nano-ceria with the same distribution of a primary size (3–5 nm), but different redox activity, were used: Ceria-p, synthesized by a precipitation route, and Ceria-h, synthesized by a hydrothermal route. Both Ceria-p and Ceria-h induced oxidative stress, inflammatory responses and cytotoxicity in mice, but their toxicological profiles were quite different. The mean size of Ceria-p agglomerates was much smaller compared to Ceria-h, thereby causing a more potent acute inflammation, due to their higher number concentration of agglomerates and higher deposition rate in the deep lung. Ceria-h had a higher reactivity to catalyzing the generation of reactive oxygen species (ROS), and caused two waves of lung injury: bronchoalveolar lavage (BAL) inflammation and cytotoxicity in the early stage and redox-activity-evoked lipid peroxidation and pro-inflammation in the latter stage. Therefore, the size distribution of ceria-containing agglomerates in the exhaust, as well as their surface chemistry are essential characteristics to assess the potential risks of using nano-ceria as a fuel additive. Molecular Diversity Preservation International (MDPI) 2014-04-10 /pmc/articles/PMC4013616/ /pubmed/24727375 http://dx.doi.org/10.3390/ijms15046072 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Peng, Lu
He, Xiao
Zhang, Peng
Zhang, Jing
Li, Yuanyuan
Zhang, Junzhe
Ma, Yuhui
Ding, Yayun
Wu, Zhenqiang
Chai, Zhifang
Zhang, Zhiyong
Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size
title Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size
title_full Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size
title_fullStr Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size
title_full_unstemmed Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size
title_short Comparative Pulmonary Toxicity of Two Ceria Nanoparticles with the Same Primary Size
title_sort comparative pulmonary toxicity of two ceria nanoparticles with the same primary size
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013616/
https://www.ncbi.nlm.nih.gov/pubmed/24727375
http://dx.doi.org/10.3390/ijms15046072
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