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Polymorphisms in DNA Repair Genes and MDR1 and the Risk for Non-Hodgkin Lymphoma
The damage caused by oxidative stress and exposure to cigarette smoke and alcohol necessitate DNA damage repair and transport by multidrug resistance-1 (MDR1). To explore the association between polymorphisms in these genes and non-Hodgkin lymphoma risk, we analyzed 15 polymorphisms of 12 genes in a...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013656/ https://www.ncbi.nlm.nih.gov/pubmed/24756092 http://dx.doi.org/10.3390/ijms15046703 |
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author | Kim, Hee Nam Kim, Nan Young Yu, Li Kim, Yeo-Kyeoung Lee, Il-Kwon Yang, Deok-Hwan Lee, Je-Jung Shin, Min-Ho Park, Kyeong-Soo Choi, Jin-Su Kim, Hyeoung-Joon |
author_facet | Kim, Hee Nam Kim, Nan Young Yu, Li Kim, Yeo-Kyeoung Lee, Il-Kwon Yang, Deok-Hwan Lee, Je-Jung Shin, Min-Ho Park, Kyeong-Soo Choi, Jin-Su Kim, Hyeoung-Joon |
author_sort | Kim, Hee Nam |
collection | PubMed |
description | The damage caused by oxidative stress and exposure to cigarette smoke and alcohol necessitate DNA damage repair and transport by multidrug resistance-1 (MDR1). To explore the association between polymorphisms in these genes and non-Hodgkin lymphoma risk, we analyzed 15 polymorphisms of 12 genes in a population-based study in Korea (694 cases and 1700 controls). Four genotypes of DNA repair pathway genes (XRCC1 399 GA, OGG1 326 GG, BRCA1 871 TT, and WRN 787 TT) were associated with a decreased risk for NHL [odds ratio (OR)(XRCC1 GA) = 0.80, p = 0.02; OR(OGG1 GG) = 0.70, p = 0.008; OR(BRCA1 TT) = 0.71, p = 0.048; OR(WRN TT) = 0.68, p = 0.01]. Conversely, the MGMT 115 CT genotype was associated with an increased risk for NHL (OR = 1.25, p = 0.04). In the MDR1 gene, the 1236 CC genotype was associated with a decreased risk for NHL (OR = 0.74, p = 0.04), and the 3435 CT and TT genotypes were associated with an increased risk (OR(3435CT) = 1.50, p < 0.0001; OR(3435TT) = 1.43, p = 0.02). These results suggest that polymorphisms in the DNA repair genes XRCC1, OGG1, BRCA1, WRN1, and MGMT and in the MDR1 gene may affect the risk for NHL in Korean patients. |
format | Online Article Text |
id | pubmed-4013656 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-40136562014-05-08 Polymorphisms in DNA Repair Genes and MDR1 and the Risk for Non-Hodgkin Lymphoma Kim, Hee Nam Kim, Nan Young Yu, Li Kim, Yeo-Kyeoung Lee, Il-Kwon Yang, Deok-Hwan Lee, Je-Jung Shin, Min-Ho Park, Kyeong-Soo Choi, Jin-Su Kim, Hyeoung-Joon Int J Mol Sci Article The damage caused by oxidative stress and exposure to cigarette smoke and alcohol necessitate DNA damage repair and transport by multidrug resistance-1 (MDR1). To explore the association between polymorphisms in these genes and non-Hodgkin lymphoma risk, we analyzed 15 polymorphisms of 12 genes in a population-based study in Korea (694 cases and 1700 controls). Four genotypes of DNA repair pathway genes (XRCC1 399 GA, OGG1 326 GG, BRCA1 871 TT, and WRN 787 TT) were associated with a decreased risk for NHL [odds ratio (OR)(XRCC1 GA) = 0.80, p = 0.02; OR(OGG1 GG) = 0.70, p = 0.008; OR(BRCA1 TT) = 0.71, p = 0.048; OR(WRN TT) = 0.68, p = 0.01]. Conversely, the MGMT 115 CT genotype was associated with an increased risk for NHL (OR = 1.25, p = 0.04). In the MDR1 gene, the 1236 CC genotype was associated with a decreased risk for NHL (OR = 0.74, p = 0.04), and the 3435 CT and TT genotypes were associated with an increased risk (OR(3435CT) = 1.50, p < 0.0001; OR(3435TT) = 1.43, p = 0.02). These results suggest that polymorphisms in the DNA repair genes XRCC1, OGG1, BRCA1, WRN1, and MGMT and in the MDR1 gene may affect the risk for NHL in Korean patients. Molecular Diversity Preservation International (MDPI) 2014-04-21 /pmc/articles/PMC4013656/ /pubmed/24756092 http://dx.doi.org/10.3390/ijms15046703 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Kim, Hee Nam Kim, Nan Young Yu, Li Kim, Yeo-Kyeoung Lee, Il-Kwon Yang, Deok-Hwan Lee, Je-Jung Shin, Min-Ho Park, Kyeong-Soo Choi, Jin-Su Kim, Hyeoung-Joon Polymorphisms in DNA Repair Genes and MDR1 and the Risk for Non-Hodgkin Lymphoma |
title | Polymorphisms in DNA Repair Genes and MDR1 and the Risk for Non-Hodgkin Lymphoma |
title_full | Polymorphisms in DNA Repair Genes and MDR1 and the Risk for Non-Hodgkin Lymphoma |
title_fullStr | Polymorphisms in DNA Repair Genes and MDR1 and the Risk for Non-Hodgkin Lymphoma |
title_full_unstemmed | Polymorphisms in DNA Repair Genes and MDR1 and the Risk for Non-Hodgkin Lymphoma |
title_short | Polymorphisms in DNA Repair Genes and MDR1 and the Risk for Non-Hodgkin Lymphoma |
title_sort | polymorphisms in dna repair genes and mdr1 and the risk for non-hodgkin lymphoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013656/ https://www.ncbi.nlm.nih.gov/pubmed/24756092 http://dx.doi.org/10.3390/ijms15046703 |
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