Design, Synthesis and Bioactivity of N-Glycosyl-N′-(5-substituted phenyl-2-furoyl) Hydrazide Derivatives

Condensation products of 5-substituted phenyl-2-furoyl hydrazide with different monosaccharides d-glucose, d-galactose,d-mannose, d-fucose and d-arabinose were prepared. The anomerization and cyclic-acyclic isomers were investigated by (1)H NMR spectroscopy. The results showed that, except for the d...

Descripción completa

Detalles Bibliográficos
Autores principales: Cui, Zining, Su, Hang, Jiang, Jiazhen, Yang, Xinling, Nishida, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013659/
https://www.ncbi.nlm.nih.gov/pubmed/24756095
http://dx.doi.org/10.3390/ijms15046741
_version_ 1782315095605379072
author Cui, Zining
Su, Hang
Jiang, Jiazhen
Yang, Xinling
Nishida, Yoshihiro
author_facet Cui, Zining
Su, Hang
Jiang, Jiazhen
Yang, Xinling
Nishida, Yoshihiro
author_sort Cui, Zining
collection PubMed
description Condensation products of 5-substituted phenyl-2-furoyl hydrazide with different monosaccharides d-glucose, d-galactose,d-mannose, d-fucose and d-arabinose were prepared. The anomerization and cyclic-acyclic isomers were investigated by (1)H NMR spectroscopy. The results showed that, except for the d-glucose derivatives, which were in the presence of β-anomeric forms, all derivatives were in an acyclic Schiff base form. Their antifungal and antitumor activities were studied. The bioassay results indicated that some title compounds showed superior effects over the commercial positive controls.
format Online
Article
Text
id pubmed-4013659
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-40136592014-05-08 Design, Synthesis and Bioactivity of N-Glycosyl-N′-(5-substituted phenyl-2-furoyl) Hydrazide Derivatives Cui, Zining Su, Hang Jiang, Jiazhen Yang, Xinling Nishida, Yoshihiro Int J Mol Sci Article Condensation products of 5-substituted phenyl-2-furoyl hydrazide with different monosaccharides d-glucose, d-galactose,d-mannose, d-fucose and d-arabinose were prepared. The anomerization and cyclic-acyclic isomers were investigated by (1)H NMR spectroscopy. The results showed that, except for the d-glucose derivatives, which were in the presence of β-anomeric forms, all derivatives were in an acyclic Schiff base form. Their antifungal and antitumor activities were studied. The bioassay results indicated that some title compounds showed superior effects over the commercial positive controls. Molecular Diversity Preservation International (MDPI) 2014-04-21 /pmc/articles/PMC4013659/ /pubmed/24756095 http://dx.doi.org/10.3390/ijms15046741 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Cui, Zining
Su, Hang
Jiang, Jiazhen
Yang, Xinling
Nishida, Yoshihiro
Design, Synthesis and Bioactivity of N-Glycosyl-N′-(5-substituted phenyl-2-furoyl) Hydrazide Derivatives
title Design, Synthesis and Bioactivity of N-Glycosyl-N′-(5-substituted phenyl-2-furoyl) Hydrazide Derivatives
title_full Design, Synthesis and Bioactivity of N-Glycosyl-N′-(5-substituted phenyl-2-furoyl) Hydrazide Derivatives
title_fullStr Design, Synthesis and Bioactivity of N-Glycosyl-N′-(5-substituted phenyl-2-furoyl) Hydrazide Derivatives
title_full_unstemmed Design, Synthesis and Bioactivity of N-Glycosyl-N′-(5-substituted phenyl-2-furoyl) Hydrazide Derivatives
title_short Design, Synthesis and Bioactivity of N-Glycosyl-N′-(5-substituted phenyl-2-furoyl) Hydrazide Derivatives
title_sort design, synthesis and bioactivity of n-glycosyl-n′-(5-substituted phenyl-2-furoyl) hydrazide derivatives
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013659/
https://www.ncbi.nlm.nih.gov/pubmed/24756095
http://dx.doi.org/10.3390/ijms15046741
work_keys_str_mv AT cuizining designsynthesisandbioactivityofnglycosyln5substitutedphenyl2furoylhydrazidederivatives
AT suhang designsynthesisandbioactivityofnglycosyln5substitutedphenyl2furoylhydrazidederivatives
AT jiangjiazhen designsynthesisandbioactivityofnglycosyln5substitutedphenyl2furoylhydrazidederivatives
AT yangxinling designsynthesisandbioactivityofnglycosyln5substitutedphenyl2furoylhydrazidederivatives
AT nishidayoshihiro designsynthesisandbioactivityofnglycosyln5substitutedphenyl2furoylhydrazidederivatives

Ejemplares similares