Single Nucleotide Polymorphisms in Growth Hormone Gene and Their Association with Growth Traits in Siniperca chuatsi (Basilewsky)

Growth hormone (GH) has been considered as a candidate gene for growth traits in fish. In this study, polymorphisms of the GH gene were evaluated for associations with growth traits in 282 Siniperca chuatsi individuals. Using directly sequencing, four single nucleotide polymorphisms (SNPs) were iden...

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Detalles Bibliográficos
Autores principales: Tian, Changxu, Yang, Min, Lv, Liyuan, Yuan, Yongchao, Liang, Xufang, Guo, Wenjie, Song, Yi, Zhao, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Short Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013676/
https://www.ncbi.nlm.nih.gov/pubmed/24758939
http://dx.doi.org/10.3390/ijms15047029
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author Tian, Changxu
Yang, Min
Lv, Liyuan
Yuan, Yongchao
Liang, Xufang
Guo, Wenjie
Song, Yi
Zhao, Cheng
author_facet Tian, Changxu
Yang, Min
Lv, Liyuan
Yuan, Yongchao
Liang, Xufang
Guo, Wenjie
Song, Yi
Zhao, Cheng
author_sort Tian, Changxu
collection PubMed
description Growth hormone (GH) has been considered as a candidate gene for growth traits in fish. In this study, polymorphisms of the GH gene were evaluated for associations with growth traits in 282 Siniperca chuatsi individuals. Using directly sequencing, four single nucleotide polymorphisms (SNPs) were identified in GH gene, with two mutations in intron 4 (g.4940A>C, g.4948A>T), one mutation in exon 5 (g.5045T>C) and one in intron 5 (g.5234T>G). Notably, three of them were significantly associated with growth performance, particularly for g.4940A>C which was highly correlated with all the four growth traits. In conclusion, our results demonstrated that these SNPs in GH gene could influence growth performance of S.chuatsi and could be used for marker-assisted selection (MAS) in this species.
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spelling pubmed-40136762014-05-08 Single Nucleotide Polymorphisms in Growth Hormone Gene and Their Association with Growth Traits in Siniperca chuatsi (Basilewsky) Tian, Changxu Yang, Min Lv, Liyuan Yuan, Yongchao Liang, Xufang Guo, Wenjie Song, Yi Zhao, Cheng Int J Mol Sci Short Note Growth hormone (GH) has been considered as a candidate gene for growth traits in fish. In this study, polymorphisms of the GH gene were evaluated for associations with growth traits in 282 Siniperca chuatsi individuals. Using directly sequencing, four single nucleotide polymorphisms (SNPs) were identified in GH gene, with two mutations in intron 4 (g.4940A>C, g.4948A>T), one mutation in exon 5 (g.5045T>C) and one in intron 5 (g.5234T>G). Notably, three of them were significantly associated with growth performance, particularly for g.4940A>C which was highly correlated with all the four growth traits. In conclusion, our results demonstrated that these SNPs in GH gene could influence growth performance of S.chuatsi and could be used for marker-assisted selection (MAS) in this species. Molecular Diversity Preservation International (MDPI) 2014-04-22 /pmc/articles/PMC4013676/ /pubmed/24758939 http://dx.doi.org/10.3390/ijms15047029 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Short Note
Tian, Changxu
Yang, Min
Lv, Liyuan
Yuan, Yongchao
Liang, Xufang
Guo, Wenjie
Song, Yi
Zhao, Cheng
Single Nucleotide Polymorphisms in Growth Hormone Gene and Their Association with Growth Traits in Siniperca chuatsi (Basilewsky)
title Single Nucleotide Polymorphisms in Growth Hormone Gene and Their Association with Growth Traits in Siniperca chuatsi (Basilewsky)
title_full Single Nucleotide Polymorphisms in Growth Hormone Gene and Their Association with Growth Traits in Siniperca chuatsi (Basilewsky)
title_fullStr Single Nucleotide Polymorphisms in Growth Hormone Gene and Their Association with Growth Traits in Siniperca chuatsi (Basilewsky)
title_full_unstemmed Single Nucleotide Polymorphisms in Growth Hormone Gene and Their Association with Growth Traits in Siniperca chuatsi (Basilewsky)
title_short Single Nucleotide Polymorphisms in Growth Hormone Gene and Their Association with Growth Traits in Siniperca chuatsi (Basilewsky)
title_sort single nucleotide polymorphisms in growth hormone gene and their association with growth traits in siniperca chuatsi (basilewsky)
topic Short Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013676/
https://www.ncbi.nlm.nih.gov/pubmed/24758939
http://dx.doi.org/10.3390/ijms15047029
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