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AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter

Superelongation complexes (SECs) are essential for transcription elongation of many human genes, including the integrated HIV-1 genome. At the HIV-1 promoter, the viral Tat protein binds simultaneously to the nascent TAR RNA and the CycT1 subunit of the P-TEFb kinase in a SEC. To understand the pref...

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Detalles Bibliográficos
Autores principales:	Schulze-Gahmen, Ursula, Lu, Huasong, Zhou, Qiang, Alber, Tom
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2014
Materias:	Biophysics and Structural Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013717/ https://www.ncbi.nlm.nih.gov/pubmed/24843025 http://dx.doi.org/10.7554/eLife.02375

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