A Preliminary Study of (13)C-Phenylalanine and (13)C-Dipeptide Breath Tests in Horses

This study aimed to establish a standard dose and sample collection time for (13)C phenylalanine and (13)C-Dipeptide breath test in horses. To evaluate dose-dependent effects, healthy horses received 2.5 mg/kg, 5 mg/kg, and 10 mg/kg (13)C phenylalanine dissolved in 1 ml/kg distilled water and 1.25 m...

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Detalles Bibliográficos
Autores principales: SASAKI, Naoki, TSUZUKI, Nao, YAMADA, Michiaki, MINAMI, Takuto, YAMADA, Haruo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Equine Science 2009
Materias:
Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013957/
https://www.ncbi.nlm.nih.gov/pubmed/24833963
http://dx.doi.org/10.1294/jes.20.7
Descripción
Sumario:This study aimed to establish a standard dose and sample collection time for (13)C phenylalanine and (13)C-Dipeptide breath test in horses. To evaluate dose-dependent effects, healthy horses received 2.5 mg/kg, 5 mg/kg, and 10 mg/kg (13)C phenylalanine dissolved in 1 ml/kg distilled water and 1.25 mg/kg, 2.5 mg/kg, and 5 mg/kg (13)C dipeptide dissolved in 2 ml/ kg distilled water. Tmax was observed during the sample collection time. For (13)C phenylalanine, the standard deviation of Cmax at 5 mg/kg was lower than that of 10 mg/kg. For (13)C dipeptide, the standard deviation of Tmax was the lowest at 5 mg/kg. This study revealed that an optimal dose for breath tests with (13)C phenylalanine and (13)C dipeptide may be 5 mg/kg in horses.

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