A Preliminary Study of (13)C-Phenylalanine and (13)C-Dipeptide Breath Tests in Horses

This study aimed to establish a standard dose and sample collection time for (13)C phenylalanine and (13)C-Dipeptide breath test in horses. To evaluate dose-dependent effects, healthy horses received 2.5 mg/kg, 5 mg/kg, and 10 mg/kg (13)C phenylalanine dissolved in 1 ml/kg distilled water and 1.25 m...

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Autores principales: SASAKI, Naoki, TSUZUKI, Nao, YAMADA, Michiaki, MINAMI, Takuto, YAMADA, Haruo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Equine Science 2009
Materias:
Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013957/
https://www.ncbi.nlm.nih.gov/pubmed/24833963
http://dx.doi.org/10.1294/jes.20.7
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author SASAKI, Naoki
TSUZUKI, Nao
YAMADA, Michiaki
MINAMI, Takuto
YAMADA, Haruo
author_facet SASAKI, Naoki
TSUZUKI, Nao
YAMADA, Michiaki
MINAMI, Takuto
YAMADA, Haruo
author_sort SASAKI, Naoki
collection PubMed
description This study aimed to establish a standard dose and sample collection time for (13)C phenylalanine and (13)C-Dipeptide breath test in horses. To evaluate dose-dependent effects, healthy horses received 2.5 mg/kg, 5 mg/kg, and 10 mg/kg (13)C phenylalanine dissolved in 1 ml/kg distilled water and 1.25 mg/kg, 2.5 mg/kg, and 5 mg/kg (13)C dipeptide dissolved in 2 ml/ kg distilled water. Tmax was observed during the sample collection time. For (13)C phenylalanine, the standard deviation of Cmax at 5 mg/kg was lower than that of 10 mg/kg. For (13)C dipeptide, the standard deviation of Tmax was the lowest at 5 mg/kg. This study revealed that an optimal dose for breath tests with (13)C phenylalanine and (13)C dipeptide may be 5 mg/kg in horses.
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spelling pubmed-40139572014-05-15 A Preliminary Study of (13)C-Phenylalanine and (13)C-Dipeptide Breath Tests in Horses SASAKI, Naoki TSUZUKI, Nao YAMADA, Michiaki MINAMI, Takuto YAMADA, Haruo J Equine Sci Note This study aimed to establish a standard dose and sample collection time for (13)C phenylalanine and (13)C-Dipeptide breath test in horses. To evaluate dose-dependent effects, healthy horses received 2.5 mg/kg, 5 mg/kg, and 10 mg/kg (13)C phenylalanine dissolved in 1 ml/kg distilled water and 1.25 mg/kg, 2.5 mg/kg, and 5 mg/kg (13)C dipeptide dissolved in 2 ml/ kg distilled water. Tmax was observed during the sample collection time. For (13)C phenylalanine, the standard deviation of Cmax at 5 mg/kg was lower than that of 10 mg/kg. For (13)C dipeptide, the standard deviation of Tmax was the lowest at 5 mg/kg. This study revealed that an optimal dose for breath tests with (13)C phenylalanine and (13)C dipeptide may be 5 mg/kg in horses. The Japanese Society of Equine Science 2009-04-17 2009 /pmc/articles/PMC4013957/ /pubmed/24833963 http://dx.doi.org/10.1294/jes.20.7 Text en 2009 The Japanese Society of Equine Science http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Note
SASAKI, Naoki
TSUZUKI, Nao
YAMADA, Michiaki
MINAMI, Takuto
YAMADA, Haruo
A Preliminary Study of (13)C-Phenylalanine and (13)C-Dipeptide Breath Tests in Horses
title A Preliminary Study of (13)C-Phenylalanine and (13)C-Dipeptide Breath Tests in Horses
title_full A Preliminary Study of (13)C-Phenylalanine and (13)C-Dipeptide Breath Tests in Horses
title_fullStr A Preliminary Study of (13)C-Phenylalanine and (13)C-Dipeptide Breath Tests in Horses
title_full_unstemmed A Preliminary Study of (13)C-Phenylalanine and (13)C-Dipeptide Breath Tests in Horses
title_short A Preliminary Study of (13)C-Phenylalanine and (13)C-Dipeptide Breath Tests in Horses
title_sort preliminary study of (13)c-phenylalanine and (13)c-dipeptide breath tests in horses
topic Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4013957/
https://www.ncbi.nlm.nih.gov/pubmed/24833963
http://dx.doi.org/10.1294/jes.20.7
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