Hitting the target: fragment screening with acoustic in situ co-crystallization of proteins plus fragment libraries on pin-mounted data-collection micromeshes

Acoustic droplet ejection (ADE) is a powerful technology that supports crystallographic applications such as growing, improving and manipulating protein crystals. A fragment-screening strategy is described that uses ADE to co-crystallize proteins with fragment libraries directly on MiTeGen MicroMesh...

Descripción completa

Detalles Bibliográficos
Autores principales: Yin, Xingyu, Scalia, Alexander, Leroy, Ludmila, Cuttitta, Christina M., Polizzo, Gina M., Ericson, Daniel L., Roessler, Christian G., Campos, Olven, Ma, Millie Y., Agarwal, Rakhi, Jackimowicz, Rick, Allaire, Marc, Orville, Allen M., Sweet, Robert M., Soares, Alexei S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014116/
https://www.ncbi.nlm.nih.gov/pubmed/24816088
http://dx.doi.org/10.1107/S1399004713034603

Ejemplares similares

Ejemplares similares