Suppressor of Cytokine Signaling 4 (SOCS4) Protects against Severe Cytokine Storm and Enhances Viral Clearance during Influenza Infection

Suppressor of cytokine signaling (SOCS) proteins are key regulators of innate and adaptive immunity. There is no described biological role for SOCS4, despite broad expression in the hematopoietic system. We demonstrate that mice lacking functional SOCS4 protein rapidly succumb to infection with a pa...

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Detalles Bibliográficos
Autores principales: Kedzierski, Lukasz, Linossi, Edmond M., Kolesnik, Tatiana B., Day, E. Bridie, Bird, Nicola L., Kile, Benjamin T., Belz, Gabrielle T., Metcalf, Donald, Nicola, Nicos A., Kedzierska, Katherine, Nicholson, Sandra E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014316/
https://www.ncbi.nlm.nih.gov/pubmed/24809749
http://dx.doi.org/10.1371/journal.ppat.1004134

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