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A Simulated Intermediate State for Folding and Aggregation Provides Insights into ΔN6 β(2)-Microglobulin Amyloidogenic Behavior

A major component of ex vivo amyloid plaques of patients with dialysis-related amyloidosis (DRA) is a cleaved variant of β(2)-microglobulin (ΔN6) lacking the first six N-terminal residues. Here we perform a computational study on ΔN6, which provides clues to understand the amyloidogenicity of the fu...

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Detalles Bibliográficos
Autores principales:	Estácio, Sílvia G., Krobath, Heinrich, Vila-Viçosa, Diogo, Machuqueiro, Miguel, Shakhnovich, Eugene I., Faísca, Patrícia F. N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014404/ https://www.ncbi.nlm.nih.gov/pubmed/24809460 http://dx.doi.org/10.1371/journal.pcbi.1003606

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