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Epistatically Interacting Substitutions Are Enriched during Adaptive Protein Evolution
Most experimental studies of epistasis in evolution have focused on adaptive changes—but adaptation accounts for only a portion of total evolutionary change. Are the patterns of epistasis during adaptation representative of evolution more broadly? We address this question by examining a pair of prot...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014419/ https://www.ncbi.nlm.nih.gov/pubmed/24811236 http://dx.doi.org/10.1371/journal.pgen.1004328 |