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Enhanced Interaction between Pseudokinase and Kinase Domains in Gcn2 stimulates eIF2α Phosphorylation in Starved Cells

The stress-activated protein kinase Gcn2 regulates protein synthesis by phosphorylation of translation initiation factor eIF2α, from yeast to mammals. The Gcn2 kinase domain (KD) is inherently inactive and requires allosteric stimulation by adjoining regulatory domains. Gcn2 contains a pseudokinase...

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Detalles Bibliográficos
Autores principales:	Lageix, Sebastien, Rothenburg, Stefan, Dever, Thomas E., Hinnebusch, Alan G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014428/ https://www.ncbi.nlm.nih.gov/pubmed/24811037 http://dx.doi.org/10.1371/journal.pgen.1004326

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