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Lifecourse Social Position and D-Dimer; Findings from the 1958 British Birth Cohort

The aim is to examine the association of lifecourse socioeconomic position (SEP) on circulating levels of D-dimer. Data from the 1958 British birth cohort were used, social class was determined at three stages of respondents' life: at birth, at 23 and at 42 years. A cumulative indicator score o...

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Autores principales: Tabassum, Faiza, Kumari, Meena, Rumley, Ann, Power, Chris, Strachan, David P., Lowe, Gordon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014469/
https://www.ncbi.nlm.nih.gov/pubmed/24809471
http://dx.doi.org/10.1371/journal.pone.0093277
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author Tabassum, Faiza
Kumari, Meena
Rumley, Ann
Power, Chris
Strachan, David P.
Lowe, Gordon
author_facet Tabassum, Faiza
Kumari, Meena
Rumley, Ann
Power, Chris
Strachan, David P.
Lowe, Gordon
author_sort Tabassum, Faiza
collection PubMed
description The aim is to examine the association of lifecourse socioeconomic position (SEP) on circulating levels of D-dimer. Data from the 1958 British birth cohort were used, social class was determined at three stages of respondents' life: at birth, at 23 and at 42 years. A cumulative indicator score of SEP (CIS) was calculated ranging from 0 (always in the highest social class) to 9 (always in the lowest social class). In men and women, associations were observed between CIS and D-dimer (P<0.05). Thus, the respondents in more disadvantaged social classes had elevated levels of D-dimer compared to respondents in less disadvantaged social class. In multivariate analyses, the association of disadvantaged social position with D-dimer was largely explained by fibrinogen, C-reactive protein and von Willebrand Factor in women, and additionally by smoking, alcohol consumption and physical activity in men. Socioeconomic circumstances across the lifecourse at various stages also contribute independently to raised levels of D-dimer in middle age in women only. Risk exposure related to SEP accumulates across life and contributes to raised levels of D-dimer. The association of haemostatic markers and social differences in health may be mediated by inflammatory and other markers.
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spelling pubmed-40144692014-05-14 Lifecourse Social Position and D-Dimer; Findings from the 1958 British Birth Cohort Tabassum, Faiza Kumari, Meena Rumley, Ann Power, Chris Strachan, David P. Lowe, Gordon PLoS One Research Article The aim is to examine the association of lifecourse socioeconomic position (SEP) on circulating levels of D-dimer. Data from the 1958 British birth cohort were used, social class was determined at three stages of respondents' life: at birth, at 23 and at 42 years. A cumulative indicator score of SEP (CIS) was calculated ranging from 0 (always in the highest social class) to 9 (always in the lowest social class). In men and women, associations were observed between CIS and D-dimer (P<0.05). Thus, the respondents in more disadvantaged social classes had elevated levels of D-dimer compared to respondents in less disadvantaged social class. In multivariate analyses, the association of disadvantaged social position with D-dimer was largely explained by fibrinogen, C-reactive protein and von Willebrand Factor in women, and additionally by smoking, alcohol consumption and physical activity in men. Socioeconomic circumstances across the lifecourse at various stages also contribute independently to raised levels of D-dimer in middle age in women only. Risk exposure related to SEP accumulates across life and contributes to raised levels of D-dimer. The association of haemostatic markers and social differences in health may be mediated by inflammatory and other markers. Public Library of Science 2014-05-08 /pmc/articles/PMC4014469/ /pubmed/24809471 http://dx.doi.org/10.1371/journal.pone.0093277 Text en © 2014 Tabassum et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Tabassum, Faiza
Kumari, Meena
Rumley, Ann
Power, Chris
Strachan, David P.
Lowe, Gordon
Lifecourse Social Position and D-Dimer; Findings from the 1958 British Birth Cohort
title Lifecourse Social Position and D-Dimer; Findings from the 1958 British Birth Cohort
title_full Lifecourse Social Position and D-Dimer; Findings from the 1958 British Birth Cohort
title_fullStr Lifecourse Social Position and D-Dimer; Findings from the 1958 British Birth Cohort
title_full_unstemmed Lifecourse Social Position and D-Dimer; Findings from the 1958 British Birth Cohort
title_short Lifecourse Social Position and D-Dimer; Findings from the 1958 British Birth Cohort
title_sort lifecourse social position and d-dimer; findings from the 1958 british birth cohort
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014469/
https://www.ncbi.nlm.nih.gov/pubmed/24809471
http://dx.doi.org/10.1371/journal.pone.0093277
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