Study on the Interaction of β-Cyclodextrin and Berberine Hydrochloride and Its Analytical Application

The fluorescence enhancement of berberine hydrochloride (BBH) as a result of complex with β-cyclodextrin (β-CD) is investigated. The mechanism of the inclusion was studied and discussed by spectrofluoremetry and infrared spectrograms. The results showed that a 1∶1 (β-CD: BBH) complex was formed with...

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Detalles Bibliográficos
Autores principales: Jia, Baoxiu, Li, Yuqin, Wang, Decai, Duan, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014474/
https://www.ncbi.nlm.nih.gov/pubmed/24810601
http://dx.doi.org/10.1371/journal.pone.0095498
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author Jia, Baoxiu
Li, Yuqin
Wang, Decai
Duan, Rui
author_facet Jia, Baoxiu
Li, Yuqin
Wang, Decai
Duan, Rui
author_sort Jia, Baoxiu
collection PubMed
description The fluorescence enhancement of berberine hydrochloride (BBH) as a result of complex with β-cyclodextrin (β-CD) is investigated. The mechanism of the inclusion was studied and discussed by spectrofluoremetry and infrared spectrograms. The results showed that a 1∶1 (β-CD: BBH) complex was formed with an apparent association constant of 4.23×10(2) L/mol. Based on the enhancement of the fluorescent intensity of berberine hydrochloride, a new spectrofluorimetric method for the determination of BBH in the presence of β-CD was developed. The linear range was 1.00∼4.00 µg/mL with the detection limit of 5.54 ng/mL. The proposed method was successfully applied to the determination of BBH in tablets.
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spelling pubmed-40144742014-05-14 Study on the Interaction of β-Cyclodextrin and Berberine Hydrochloride and Its Analytical Application Jia, Baoxiu Li, Yuqin Wang, Decai Duan, Rui PLoS One Research Article The fluorescence enhancement of berberine hydrochloride (BBH) as a result of complex with β-cyclodextrin (β-CD) is investigated. The mechanism of the inclusion was studied and discussed by spectrofluoremetry and infrared spectrograms. The results showed that a 1∶1 (β-CD: BBH) complex was formed with an apparent association constant of 4.23×10(2) L/mol. Based on the enhancement of the fluorescent intensity of berberine hydrochloride, a new spectrofluorimetric method for the determination of BBH in the presence of β-CD was developed. The linear range was 1.00∼4.00 µg/mL with the detection limit of 5.54 ng/mL. The proposed method was successfully applied to the determination of BBH in tablets. Public Library of Science 2014-05-08 /pmc/articles/PMC4014474/ /pubmed/24810601 http://dx.doi.org/10.1371/journal.pone.0095498 Text en © 2014 Jia et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Jia, Baoxiu
Li, Yuqin
Wang, Decai
Duan, Rui
Study on the Interaction of β-Cyclodextrin and Berberine Hydrochloride and Its Analytical Application
title Study on the Interaction of β-Cyclodextrin and Berberine Hydrochloride and Its Analytical Application
title_full Study on the Interaction of β-Cyclodextrin and Berberine Hydrochloride and Its Analytical Application
title_fullStr Study on the Interaction of β-Cyclodextrin and Berberine Hydrochloride and Its Analytical Application
title_full_unstemmed Study on the Interaction of β-Cyclodextrin and Berberine Hydrochloride and Its Analytical Application
title_short Study on the Interaction of β-Cyclodextrin and Berberine Hydrochloride and Its Analytical Application
title_sort study on the interaction of β-cyclodextrin and berberine hydrochloride and its analytical application
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014474/
https://www.ncbi.nlm.nih.gov/pubmed/24810601
http://dx.doi.org/10.1371/journal.pone.0095498
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