Genetic Interactions with Sex Make a Relatively Small Contribution to the Heritability of Complex Traits in Mice

The extent to which sex-specific genetic effects contribute to phenotypic variation is largely unknown. We applied a novel Bayesian method, sparse partitioning, to detect gene by sex (GxS) and gene by gene (GxG) quantitative loci (QTLs) in 1,900 outbred heterogeneous stock mice. In an analysis of 55...

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Autores principales: Krohn, Jon, Speed, Doug, Palme, Rupert, Touma, Chadi, Mott, Richard, Flint, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014490/
https://www.ncbi.nlm.nih.gov/pubmed/24811081
http://dx.doi.org/10.1371/journal.pone.0096450
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author Krohn, Jon
Speed, Doug
Palme, Rupert
Touma, Chadi
Mott, Richard
Flint, Jonathan
author_facet Krohn, Jon
Speed, Doug
Palme, Rupert
Touma, Chadi
Mott, Richard
Flint, Jonathan
author_sort Krohn, Jon
collection PubMed
description The extent to which sex-specific genetic effects contribute to phenotypic variation is largely unknown. We applied a novel Bayesian method, sparse partitioning, to detect gene by sex (GxS) and gene by gene (GxG) quantitative loci (QTLs) in 1,900 outbred heterogeneous stock mice. In an analysis of 55 phenotypes, we detected 16 GxS and 6 GxG QTLs. The increase in the amount of phenotypic variance explained by models including GxS was small, ranging from 0.14% to 4.30%. We conclude that GxS rarely make a large overall contribution to the heritability of phenotypes, however there are cases where these will be individually important.
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spelling pubmed-40144902014-05-14 Genetic Interactions with Sex Make a Relatively Small Contribution to the Heritability of Complex Traits in Mice Krohn, Jon Speed, Doug Palme, Rupert Touma, Chadi Mott, Richard Flint, Jonathan PLoS One Research Article The extent to which sex-specific genetic effects contribute to phenotypic variation is largely unknown. We applied a novel Bayesian method, sparse partitioning, to detect gene by sex (GxS) and gene by gene (GxG) quantitative loci (QTLs) in 1,900 outbred heterogeneous stock mice. In an analysis of 55 phenotypes, we detected 16 GxS and 6 GxG QTLs. The increase in the amount of phenotypic variance explained by models including GxS was small, ranging from 0.14% to 4.30%. We conclude that GxS rarely make a large overall contribution to the heritability of phenotypes, however there are cases where these will be individually important. Public Library of Science 2014-05-08 /pmc/articles/PMC4014490/ /pubmed/24811081 http://dx.doi.org/10.1371/journal.pone.0096450 Text en © 2014 Krohn et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Krohn, Jon
Speed, Doug
Palme, Rupert
Touma, Chadi
Mott, Richard
Flint, Jonathan
Genetic Interactions with Sex Make a Relatively Small Contribution to the Heritability of Complex Traits in Mice
title Genetic Interactions with Sex Make a Relatively Small Contribution to the Heritability of Complex Traits in Mice
title_full Genetic Interactions with Sex Make a Relatively Small Contribution to the Heritability of Complex Traits in Mice
title_fullStr Genetic Interactions with Sex Make a Relatively Small Contribution to the Heritability of Complex Traits in Mice
title_full_unstemmed Genetic Interactions with Sex Make a Relatively Small Contribution to the Heritability of Complex Traits in Mice
title_short Genetic Interactions with Sex Make a Relatively Small Contribution to the Heritability of Complex Traits in Mice
title_sort genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014490/
https://www.ncbi.nlm.nih.gov/pubmed/24811081
http://dx.doi.org/10.1371/journal.pone.0096450
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