ROS-Mediated Autophagy Induced by Dysregulation of Lipid Metabolism Plays a Protective Role in Colorectal Cancer Cells Treated with Gambogic Acid

Gambogic acid (GA), the main active component of gamboge resin, has potent antitumor activity both in vivo and in vitro. However, the underlying molecular mechanisms remain unclear. In this study, we found that GA could initiate autophagy in colorectal cancer cells, and inhibition of the autophagy p...

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Detalles Bibliográficos
Autores principales: Zhang, Haiyuan, Lei, Yunlong, Yuan, Ping, Li, Lingjun, Luo, Chao, Gao, Rui, Tian, Jun, Feng, Zuohua, Nice, Edouard C., Sun, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014500/
https://www.ncbi.nlm.nih.gov/pubmed/24810758
http://dx.doi.org/10.1371/journal.pone.0096418

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