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Structure and Inhibition of Mouse Leukotriene C(4) Synthase

Leukotriene (LT) C(4) synthase (LTC4S) is an integral membrane protein that catalyzes the conjugation reaction between the fatty acid LTA(4) and GSH to form the pro-inflammatory LTC(4), an important mediator of asthma. Mouse models of inflammatory disorders such as asthma are key to improve our unde...

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Detalles Bibliográficos
Autores principales:	Niegowski, Damian, Kleinschmidt, Thea, Ahmad, Shabbir, Qureshi, Abdul Aziz, Mårback, Michaela, Rinaldo-Matthis, Agnes, Haeggström, Jesper Z.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014545/ https://www.ncbi.nlm.nih.gov/pubmed/24810165 http://dx.doi.org/10.1371/journal.pone.0096763

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