Muscle RING Finger-1 Promotes a Maladaptive Phenotype in Chronic Hypoxia-Induced Right Ventricular Remodeling

Exposure to chronic hypoxia (CH) induces elevated pulmonary artery pressure/resistance, leading to an eventual maladaptive right ventricular hypertrophy (RVH). Muscle RING finger-1 (MuRF1) is a muscle-specific ubiquitin ligase that mediates myocyte atrophy and has been shown to play a role in left v...

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Detalles Bibliográficos
Autores principales: Campen, Matthew J., Paffett, Michael L., Colombo, E. Sage, Lucas, Selita N., Anderson, Tamara, Nysus, Monique, Norenberg, Jeffrey P., Gershman, Ben, Hesterman, Jacob, Hoppin, Jack, Willis, Monte
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014601/
https://www.ncbi.nlm.nih.gov/pubmed/24811453
http://dx.doi.org/10.1371/journal.pone.0097084

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