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Radiolabeling of Nanoparticles and Polymers for PET Imaging
Nanomedicine has become an emerging field in imaging and therapy of malignancies. Nanodimensional drug delivery systems have already been used in the clinic, as carriers for sensitive chemotherapeutics or highly toxic substances. In addition, those nanodimensional structures are further able to carr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014699/ https://www.ncbi.nlm.nih.gov/pubmed/24699244 http://dx.doi.org/10.3390/ph7040392 |
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author | Stockhofe, Katharina Postema, Johannes M. Schieferstein, Hanno Ross, Tobias L. |
author_facet | Stockhofe, Katharina Postema, Johannes M. Schieferstein, Hanno Ross, Tobias L. |
author_sort | Stockhofe, Katharina |
collection | PubMed |
description | Nanomedicine has become an emerging field in imaging and therapy of malignancies. Nanodimensional drug delivery systems have already been used in the clinic, as carriers for sensitive chemotherapeutics or highly toxic substances. In addition, those nanodimensional structures are further able to carry and deliver radionuclides. In the development process, non-invasive imaging by means of positron emission tomography (PET) represents an ideal tool for investigations of pharmacological profiles and to find the optimal nanodimensional architecture of the aimed-at drug delivery system. Furthermore, in a personalized therapy approach, molecular imaging modalities are essential for patient screening/selection and monitoring. Hence, labeling methods for potential drug delivery systems are an indispensable need to provide the radiolabeled analog. In this review, we describe and discuss various approaches and methods for the labeling of potential drug delivery systems using positron emitters. |
format | Online Article Text |
id | pubmed-4014699 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-40146992014-05-09 Radiolabeling of Nanoparticles and Polymers for PET Imaging Stockhofe, Katharina Postema, Johannes M. Schieferstein, Hanno Ross, Tobias L. Pharmaceuticals (Basel) Review Nanomedicine has become an emerging field in imaging and therapy of malignancies. Nanodimensional drug delivery systems have already been used in the clinic, as carriers for sensitive chemotherapeutics or highly toxic substances. In addition, those nanodimensional structures are further able to carry and deliver radionuclides. In the development process, non-invasive imaging by means of positron emission tomography (PET) represents an ideal tool for investigations of pharmacological profiles and to find the optimal nanodimensional architecture of the aimed-at drug delivery system. Furthermore, in a personalized therapy approach, molecular imaging modalities are essential for patient screening/selection and monitoring. Hence, labeling methods for potential drug delivery systems are an indispensable need to provide the radiolabeled analog. In this review, we describe and discuss various approaches and methods for the labeling of potential drug delivery systems using positron emitters. MDPI 2014-04-02 /pmc/articles/PMC4014699/ /pubmed/24699244 http://dx.doi.org/10.3390/ph7040392 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Stockhofe, Katharina Postema, Johannes M. Schieferstein, Hanno Ross, Tobias L. Radiolabeling of Nanoparticles and Polymers for PET Imaging |
title | Radiolabeling of Nanoparticles and Polymers for PET Imaging |
title_full | Radiolabeling of Nanoparticles and Polymers for PET Imaging |
title_fullStr | Radiolabeling of Nanoparticles and Polymers for PET Imaging |
title_full_unstemmed | Radiolabeling of Nanoparticles and Polymers for PET Imaging |
title_short | Radiolabeling of Nanoparticles and Polymers for PET Imaging |
title_sort | radiolabeling of nanoparticles and polymers for pet imaging |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014699/ https://www.ncbi.nlm.nih.gov/pubmed/24699244 http://dx.doi.org/10.3390/ph7040392 |
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