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Radiolabeling of Nanoparticles and Polymers for PET Imaging

Nanomedicine has become an emerging field in imaging and therapy of malignancies. Nanodimensional drug delivery systems have already been used in the clinic, as carriers for sensitive chemotherapeutics or highly toxic substances. In addition, those nanodimensional structures are further able to carr...

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Autores principales: Stockhofe, Katharina, Postema, Johannes M., Schieferstein, Hanno, Ross, Tobias L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014699/
https://www.ncbi.nlm.nih.gov/pubmed/24699244
http://dx.doi.org/10.3390/ph7040392
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author Stockhofe, Katharina
Postema, Johannes M.
Schieferstein, Hanno
Ross, Tobias L.
author_facet Stockhofe, Katharina
Postema, Johannes M.
Schieferstein, Hanno
Ross, Tobias L.
author_sort Stockhofe, Katharina
collection PubMed
description Nanomedicine has become an emerging field in imaging and therapy of malignancies. Nanodimensional drug delivery systems have already been used in the clinic, as carriers for sensitive chemotherapeutics or highly toxic substances. In addition, those nanodimensional structures are further able to carry and deliver radionuclides. In the development process, non-invasive imaging by means of positron emission tomography (PET) represents an ideal tool for investigations of pharmacological profiles and to find the optimal nanodimensional architecture of the aimed-at drug delivery system. Furthermore, in a personalized therapy approach, molecular imaging modalities are essential for patient screening/selection and monitoring. Hence, labeling methods for potential drug delivery systems are an indispensable need to provide the radiolabeled analog. In this review, we describe and discuss various approaches and methods for the labeling of potential drug delivery systems using positron emitters.
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spelling pubmed-40146992014-05-09 Radiolabeling of Nanoparticles and Polymers for PET Imaging Stockhofe, Katharina Postema, Johannes M. Schieferstein, Hanno Ross, Tobias L. Pharmaceuticals (Basel) Review Nanomedicine has become an emerging field in imaging and therapy of malignancies. Nanodimensional drug delivery systems have already been used in the clinic, as carriers for sensitive chemotherapeutics or highly toxic substances. In addition, those nanodimensional structures are further able to carry and deliver radionuclides. In the development process, non-invasive imaging by means of positron emission tomography (PET) represents an ideal tool for investigations of pharmacological profiles and to find the optimal nanodimensional architecture of the aimed-at drug delivery system. Furthermore, in a personalized therapy approach, molecular imaging modalities are essential for patient screening/selection and monitoring. Hence, labeling methods for potential drug delivery systems are an indispensable need to provide the radiolabeled analog. In this review, we describe and discuss various approaches and methods for the labeling of potential drug delivery systems using positron emitters. MDPI 2014-04-02 /pmc/articles/PMC4014699/ /pubmed/24699244 http://dx.doi.org/10.3390/ph7040392 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Stockhofe, Katharina
Postema, Johannes M.
Schieferstein, Hanno
Ross, Tobias L.
Radiolabeling of Nanoparticles and Polymers for PET Imaging
title Radiolabeling of Nanoparticles and Polymers for PET Imaging
title_full Radiolabeling of Nanoparticles and Polymers for PET Imaging
title_fullStr Radiolabeling of Nanoparticles and Polymers for PET Imaging
title_full_unstemmed Radiolabeling of Nanoparticles and Polymers for PET Imaging
title_short Radiolabeling of Nanoparticles and Polymers for PET Imaging
title_sort radiolabeling of nanoparticles and polymers for pet imaging
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014699/
https://www.ncbi.nlm.nih.gov/pubmed/24699244
http://dx.doi.org/10.3390/ph7040392
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