Amino Acid Prodrugs: An Approach to Improve the Absorption of HIV-1 Protease Inhibitor, Lopinavir

Poor systemic concentrations of lopinavir (LPV) following oral administration occur due to high cellular efflux by P-glycoprotein (P-gp) and multidrug resistance-associated proteins (MRPs) and extensive metabolism by CYP3A4 enzymes. In this study, amino acid prodrugs of LPV were designed and investi...

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Detalles Bibliográficos
Autores principales: Patel, Mitesh, Mandava, Nanda, Gokulgandhi, Mitan, Pal, Dhananjay, Mitra, Ashim K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014701/
https://www.ncbi.nlm.nih.gov/pubmed/24727459
http://dx.doi.org/10.3390/ph7040433

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014701/
https://www.ncbi.nlm.nih.gov/pubmed/24727459
http://dx.doi.org/10.3390/ph7040433

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