Synthesis, In Vitro and In Vivo Evaluation of the N-ethoxycarbonylmorpholine Ester of Diclofenac as a Prodrug

The N-ethoxycarbonylmorpholine moiety was evaluated as a novel prodrug moiety for carboxylic acid containing drugs represented by diclofenac (1). Compound 2, the N-ethoxycarbonylmorpholine ester of diclofenac was synthesized and evaluated as a potential prodrug. The stability of the synthesized prod...

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Detalles Bibliográficos
Autores principales: Jilani, Jamal A., Idkaidek, Nasir M., Alzoubi, Karem H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014702/
https://www.ncbi.nlm.nih.gov/pubmed/24736104
http://dx.doi.org/10.3390/ph7040453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014702/
https://www.ncbi.nlm.nih.gov/pubmed/24736104
http://dx.doi.org/10.3390/ph7040453

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