Matrix and Backstage: Cellular Substrates for Viral Vaccines

Vaccines are complex products that are manufactured in highly dynamic processes. Cellular substrates are one critical component that can have an enormous impact on reactogenicity of the final preparation, level of attenuation of a live virus, yield of infectious units or antigens, and cost per vacci...

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Detalles Bibliográficos
Autores principales: Jordan, Ingo, Sandig, Volker
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014716/
https://www.ncbi.nlm.nih.gov/pubmed/24732259
http://dx.doi.org/10.3390/v6041672
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author Jordan, Ingo
Sandig, Volker
author_facet Jordan, Ingo
Sandig, Volker
author_sort Jordan, Ingo
collection PubMed
description Vaccines are complex products that are manufactured in highly dynamic processes. Cellular substrates are one critical component that can have an enormous impact on reactogenicity of the final preparation, level of attenuation of a live virus, yield of infectious units or antigens, and cost per vaccine dose. Such parameters contribute to feasibility and affordability of vaccine programs both in industrialized countries and developing regions. This review summarizes the diversity of cellular substrates for propagation of viral vaccines from primary tissue explants and embryonated chicken eggs to designed continuous cell lines of human and avian origin.
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spelling pubmed-40147162014-05-09 Matrix and Backstage: Cellular Substrates for Viral Vaccines Jordan, Ingo Sandig, Volker Viruses Review Vaccines are complex products that are manufactured in highly dynamic processes. Cellular substrates are one critical component that can have an enormous impact on reactogenicity of the final preparation, level of attenuation of a live virus, yield of infectious units or antigens, and cost per vaccine dose. Such parameters contribute to feasibility and affordability of vaccine programs both in industrialized countries and developing regions. This review summarizes the diversity of cellular substrates for propagation of viral vaccines from primary tissue explants and embryonated chicken eggs to designed continuous cell lines of human and avian origin. MDPI 2014-04-11 /pmc/articles/PMC4014716/ /pubmed/24732259 http://dx.doi.org/10.3390/v6041672 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Jordan, Ingo
Sandig, Volker
Matrix and Backstage: Cellular Substrates for Viral Vaccines
title Matrix and Backstage: Cellular Substrates for Viral Vaccines
title_full Matrix and Backstage: Cellular Substrates for Viral Vaccines
title_fullStr Matrix and Backstage: Cellular Substrates for Viral Vaccines
title_full_unstemmed Matrix and Backstage: Cellular Substrates for Viral Vaccines
title_short Matrix and Backstage: Cellular Substrates for Viral Vaccines
title_sort matrix and backstage: cellular substrates for viral vaccines
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014716/
https://www.ncbi.nlm.nih.gov/pubmed/24732259
http://dx.doi.org/10.3390/v6041672
work_keys_str_mv AT jordaningo matrixandbackstagecellularsubstratesforviralvaccines
AT sandigvolker matrixandbackstagecellularsubstratesforviralvaccines

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