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The role of Wnt signaling pathway in carcinogenesis and implications for anticancer therapeutics
The Wnt proteins are a family of 19 secreted glycoproteins that occupy crucial roles in the regulation of processes such as cell survival, proliferation, migration and polarity, cell fate specification, body axis patterning and self-renewal in stem cells. The canonical pathway has been implicated in...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014746/ https://www.ncbi.nlm.nih.gov/pubmed/24817919 http://dx.doi.org/10.1186/1897-4287-12-13 |
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| author | Sheikh, Asfandyar Niazi, Asfandyar Khan Ahmed, Muhammad Zafar Iqbal, Bushra Anwer, Syed Muhammad Saad Khan, Hira Hussain |
| author_facet | Sheikh, Asfandyar Niazi, Asfandyar Khan Ahmed, Muhammad Zafar Iqbal, Bushra Anwer, Syed Muhammad Saad Khan, Hira Hussain |
| author_sort | Sheikh, Asfandyar |
| collection | PubMed |
| description | The Wnt proteins are a family of 19 secreted glycoproteins that occupy crucial roles in the regulation of processes such as cell survival, proliferation, migration and polarity, cell fate specification, body axis patterning and self-renewal in stem cells. The canonical pathway has been implicated in a variety of cancers. As such, it is only fair to conclude that therapies targeting the Wnt pathway may play an essential role in the future of anticancer therapeutics, both alone or in conjunction with traditional therapies. |
| format | Online Article Text |
| id | pubmed-4014746 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | BioMed Central |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-40147462014-05-10 The role of Wnt signaling pathway in carcinogenesis and implications for anticancer therapeutics Sheikh, Asfandyar Niazi, Asfandyar Khan Ahmed, Muhammad Zafar Iqbal, Bushra Anwer, Syed Muhammad Saad Khan, Hira Hussain Hered Cancer Clin Pract Letter to the Editor The Wnt proteins are a family of 19 secreted glycoproteins that occupy crucial roles in the regulation of processes such as cell survival, proliferation, migration and polarity, cell fate specification, body axis patterning and self-renewal in stem cells. The canonical pathway has been implicated in a variety of cancers. As such, it is only fair to conclude that therapies targeting the Wnt pathway may play an essential role in the future of anticancer therapeutics, both alone or in conjunction with traditional therapies. BioMed Central 2014-04-22 /pmc/articles/PMC4014746/ /pubmed/24817919 http://dx.doi.org/10.1186/1897-4287-12-13 Text en Copyright © 2014 Sheikh et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
| spellingShingle | Letter to the Editor Sheikh, Asfandyar Niazi, Asfandyar Khan Ahmed, Muhammad Zafar Iqbal, Bushra Anwer, Syed Muhammad Saad Khan, Hira Hussain The role of Wnt signaling pathway in carcinogenesis and implications for anticancer therapeutics |
| title | The role of Wnt signaling pathway in carcinogenesis and implications for anticancer therapeutics |
| title_full | The role of Wnt signaling pathway in carcinogenesis and implications for anticancer therapeutics |
| title_fullStr | The role of Wnt signaling pathway in carcinogenesis and implications for anticancer therapeutics |
| title_full_unstemmed | The role of Wnt signaling pathway in carcinogenesis and implications for anticancer therapeutics |
| title_short | The role of Wnt signaling pathway in carcinogenesis and implications for anticancer therapeutics |
| title_sort | role of wnt signaling pathway in carcinogenesis and implications for anticancer therapeutics |
| topic | Letter to the Editor |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014746/ https://www.ncbi.nlm.nih.gov/pubmed/24817919 http://dx.doi.org/10.1186/1897-4287-12-13 |
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