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Fulminant type 1 diabetes mellitus associated with a reactivation of Epstein–Barr virus that developed in the course of chemotherapy of multiple myeloma

A 70‐year‐old woman who was diagnosed with multiple myeloma underwent chemotherapy. Three months after beginning chemotherapy, she was readmitted to the hospital because of fever and hepatopathy. Her elevated Epstein–Barr virus (EBV) antibody levels showed that the hepatopathy was caused by reactiva...

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Autores principales: Fujiya, Atsushi, Ochiai, Hiroshi, Mizukoshi, Toshihiro, Kiyota, Atsushi, Shibata, Taiga, Suzuki, Atsushi, Ohashi, Norimi, Sobajima, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014894/
https://www.ncbi.nlm.nih.gov/pubmed/24843446
http://dx.doi.org/10.1111/j.2040-1124.2010.00061.x
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author Fujiya, Atsushi
Ochiai, Hiroshi
Mizukoshi, Toshihiro
Kiyota, Atsushi
Shibata, Taiga
Suzuki, Atsushi
Ohashi, Norimi
Sobajima, Hiroshi
author_facet Fujiya, Atsushi
Ochiai, Hiroshi
Mizukoshi, Toshihiro
Kiyota, Atsushi
Shibata, Taiga
Suzuki, Atsushi
Ohashi, Norimi
Sobajima, Hiroshi
author_sort Fujiya, Atsushi
collection PubMed
description A 70‐year‐old woman who was diagnosed with multiple myeloma underwent chemotherapy. Three months after beginning chemotherapy, she was readmitted to the hospital because of fever and hepatopathy. Her elevated Epstein–Barr virus (EBV) antibody levels showed that the hepatopathy was caused by reactivation of EBV. On the 18th hospital day, the levels of fasting plasma glucose (FPG; 451 mg/dL) and pancreatic enzymes were suddenly elevated. Elevation of HbA(1c) level (6.4%) was slight, as compared with that of the FPG level. Arterial blood gas analysis showed metabolic acidosis and diabetic ketoacidosis was suspected. The serum C‐peptide level was below the detectable limit both before and after glucagon load, thereby suggesting an insulin‐dependent state. These features were identical to the features for fulminant type 1 diabetes mellitus. The levels of EBV anti‐viral capsid antigen immunoglobulin M decreased, and the clinical course was identical to that associated with reactivation of EBV infection. (J Diabetes Invest, doi: 10.1111/j.2040.1124.2010.00061.x, 2010)
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spelling pubmed-40148942014-05-19 Fulminant type 1 diabetes mellitus associated with a reactivation of Epstein–Barr virus that developed in the course of chemotherapy of multiple myeloma Fujiya, Atsushi Ochiai, Hiroshi Mizukoshi, Toshihiro Kiyota, Atsushi Shibata, Taiga Suzuki, Atsushi Ohashi, Norimi Sobajima, Hiroshi J Diabetes Investig Articles A 70‐year‐old woman who was diagnosed with multiple myeloma underwent chemotherapy. Three months after beginning chemotherapy, she was readmitted to the hospital because of fever and hepatopathy. Her elevated Epstein–Barr virus (EBV) antibody levels showed that the hepatopathy was caused by reactivation of EBV. On the 18th hospital day, the levels of fasting plasma glucose (FPG; 451 mg/dL) and pancreatic enzymes were suddenly elevated. Elevation of HbA(1c) level (6.4%) was slight, as compared with that of the FPG level. Arterial blood gas analysis showed metabolic acidosis and diabetic ketoacidosis was suspected. The serum C‐peptide level was below the detectable limit both before and after glucagon load, thereby suggesting an insulin‐dependent state. These features were identical to the features for fulminant type 1 diabetes mellitus. The levels of EBV anti‐viral capsid antigen immunoglobulin M decreased, and the clinical course was identical to that associated with reactivation of EBV infection. (J Diabetes Invest, doi: 10.1111/j.2040.1124.2010.00061.x, 2010) Blackwell Publishing Ltd 2010-09-14 2010-12-03 /pmc/articles/PMC4014894/ /pubmed/24843446 http://dx.doi.org/10.1111/j.2040-1124.2010.00061.x Text en © 2010 Asian Association for the Study of Diabetes and Blackwell Publishing Asia Pty Ltd
spellingShingle Articles
Fujiya, Atsushi
Ochiai, Hiroshi
Mizukoshi, Toshihiro
Kiyota, Atsushi
Shibata, Taiga
Suzuki, Atsushi
Ohashi, Norimi
Sobajima, Hiroshi
Fulminant type 1 diabetes mellitus associated with a reactivation of Epstein–Barr virus that developed in the course of chemotherapy of multiple myeloma
title Fulminant type 1 diabetes mellitus associated with a reactivation of Epstein–Barr virus that developed in the course of chemotherapy of multiple myeloma
title_full Fulminant type 1 diabetes mellitus associated with a reactivation of Epstein–Barr virus that developed in the course of chemotherapy of multiple myeloma
title_fullStr Fulminant type 1 diabetes mellitus associated with a reactivation of Epstein–Barr virus that developed in the course of chemotherapy of multiple myeloma
title_full_unstemmed Fulminant type 1 diabetes mellitus associated with a reactivation of Epstein–Barr virus that developed in the course of chemotherapy of multiple myeloma
title_short Fulminant type 1 diabetes mellitus associated with a reactivation of Epstein–Barr virus that developed in the course of chemotherapy of multiple myeloma
title_sort fulminant type 1 diabetes mellitus associated with a reactivation of epstein–barr virus that developed in the course of chemotherapy of multiple myeloma
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014894/
https://www.ncbi.nlm.nih.gov/pubmed/24843446
http://dx.doi.org/10.1111/j.2040-1124.2010.00061.x
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