Cargando…

Prediction of near‐future glycated hemoglobin levels using glycated albumin levels before and after treatment for diabetes

Aims/Introduction:  In the present study, whether near‐future glycated hemoglobin (A1C) levels could be predicted by changes in glycated albumin (GA) levels before and after treatment for diabetes was investigated. Materials and Methods:  After starting diabetes treatment, GA and A1C levels are assu...

Descripción completa

Detalles Bibliográficos
Autores principales: Koga, Masafumi, Murai, Jun, Saito, Hiroshi, Kasayama, Soji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014972/
https://www.ncbi.nlm.nih.gov/pubmed/24843503
http://dx.doi.org/10.1111/j.2040-1124.2011.00107.x
_version_ 1782315270257246208
author Koga, Masafumi
Murai, Jun
Saito, Hiroshi
Kasayama, Soji
author_facet Koga, Masafumi
Murai, Jun
Saito, Hiroshi
Kasayama, Soji
author_sort Koga, Masafumi
collection PubMed
description Aims/Introduction:  In the present study, whether near‐future glycated hemoglobin (A1C) levels could be predicted by changes in glycated albumin (GA) levels before and after treatment for diabetes was investigated. Materials and Methods:  After starting diabetes treatment, GA and A1C levels are assumed to change exponentially. From this assumption, the equation for predicting near‐future GA and A1C levels was derived. A total of 54 patients with type 2 diabetes mellitus in whom diabetes treatment was initiated or altered were enrolled. By incorporating GA and A1C values before and 2–4 weeks after starting treatment (second visit) into the equation, the predicted GA and A1C levels at the third visit (5–7 weeks after treatment) were obtained. Results:  A strong and positive correlation was observed between predicted GA and measured GA at the third visit (R = 0.669, P < 0.0001). Similarly, a strong and positive correlation was observed between the predicted A1C and the measured A1C at the third visit (R = 0.795, P < 0.0001). Conclusions:  GA and A1C levels 1–3 months after starting diabetes treatment could be predicted using the equation developed. The prediction of near‐future A1C levels using GA levels at two points would be useful for judging the effectiveness of ongoing diabetes treatment at an earlier stage. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2011.00107.x, 2011)
format Online
Article
Text
id pubmed-4014972
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Blackwell Publishing Ltd
record_format MEDLINE/PubMed
spelling pubmed-40149722014-05-19 Prediction of near‐future glycated hemoglobin levels using glycated albumin levels before and after treatment for diabetes Koga, Masafumi Murai, Jun Saito, Hiroshi Kasayama, Soji J Diabetes Investig Articles Aims/Introduction:  In the present study, whether near‐future glycated hemoglobin (A1C) levels could be predicted by changes in glycated albumin (GA) levels before and after treatment for diabetes was investigated. Materials and Methods:  After starting diabetes treatment, GA and A1C levels are assumed to change exponentially. From this assumption, the equation for predicting near‐future GA and A1C levels was derived. A total of 54 patients with type 2 diabetes mellitus in whom diabetes treatment was initiated or altered were enrolled. By incorporating GA and A1C values before and 2–4 weeks after starting treatment (second visit) into the equation, the predicted GA and A1C levels at the third visit (5–7 weeks after treatment) were obtained. Results:  A strong and positive correlation was observed between predicted GA and measured GA at the third visit (R = 0.669, P < 0.0001). Similarly, a strong and positive correlation was observed between the predicted A1C and the measured A1C at the third visit (R = 0.795, P < 0.0001). Conclusions:  GA and A1C levels 1–3 months after starting diabetes treatment could be predicted using the equation developed. The prediction of near‐future A1C levels using GA levels at two points would be useful for judging the effectiveness of ongoing diabetes treatment at an earlier stage. (J Diabetes Invest, doi: 10.1111/j.2040‐1124.2011.00107.x, 2011) Blackwell Publishing Ltd 2011-08-02 2011-03-07 /pmc/articles/PMC4014972/ /pubmed/24843503 http://dx.doi.org/10.1111/j.2040-1124.2011.00107.x Text en © 2011 Asian Association for the Study of Diabetes and Blackwell Publishing Asia Pty Ltd
spellingShingle Articles
Koga, Masafumi
Murai, Jun
Saito, Hiroshi
Kasayama, Soji
Prediction of near‐future glycated hemoglobin levels using glycated albumin levels before and after treatment for diabetes
title Prediction of near‐future glycated hemoglobin levels using glycated albumin levels before and after treatment for diabetes
title_full Prediction of near‐future glycated hemoglobin levels using glycated albumin levels before and after treatment for diabetes
title_fullStr Prediction of near‐future glycated hemoglobin levels using glycated albumin levels before and after treatment for diabetes
title_full_unstemmed Prediction of near‐future glycated hemoglobin levels using glycated albumin levels before and after treatment for diabetes
title_short Prediction of near‐future glycated hemoglobin levels using glycated albumin levels before and after treatment for diabetes
title_sort prediction of near‐future glycated hemoglobin levels using glycated albumin levels before and after treatment for diabetes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014972/
https://www.ncbi.nlm.nih.gov/pubmed/24843503
http://dx.doi.org/10.1111/j.2040-1124.2011.00107.x
work_keys_str_mv AT kogamasafumi predictionofnearfutureglycatedhemoglobinlevelsusingglycatedalbuminlevelsbeforeandaftertreatmentfordiabetes
AT muraijun predictionofnearfutureglycatedhemoglobinlevelsusingglycatedalbuminlevelsbeforeandaftertreatmentfordiabetes
AT saitohiroshi predictionofnearfutureglycatedhemoglobinlevelsusingglycatedalbuminlevelsbeforeandaftertreatmentfordiabetes
AT kasayamasoji predictionofnearfutureglycatedhemoglobinlevelsusingglycatedalbuminlevelsbeforeandaftertreatmentfordiabetes