Paclitaxel sensitivity in relation to ABCB1 expression, efflux and single nucleotide polymorphisms in ovarian cancer

ABCB1 (adenosine triphosphate-binding cassette transporter B1) mediates cellular elimination of many chemotherapeutic agents including paclitaxel, which is commonly used to treat ovarian cancer. A significant association between common single nucleotide polymorphisms (SNPs) in ABCB1 and progression-...

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Detalles Bibliográficos
Autores principales: Gao, Bo, Russell, Amanda, Beesley, Jonathan, Chen, Xiao Qing, Healey, Sue, Henderson, Michelle, Wong, Mark, Emmanuel, Catherine, Galletta, Laura, Johnatty, Sharon E., Bowtell, David, Haber, Michelle, Norris, Murray, Harnett, Paul, Chenevix-Trench, Georgia, Balleine, Rosemary L., deFazio, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015028/
https://www.ncbi.nlm.nih.gov/pubmed/24810093
http://dx.doi.org/10.1038/srep04669

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