Diversity of the piRNA pathway for nonself silencing: worm-specific piRNA biogenesis factors

The PIWI-interacting RNA (piRNA) pathway protects animal germline cells from transposable elements and other genomic invaders. Although the genome defense function of piRNAs has been well established, the mechanisms of their biogenesis remain poorly understood. In this issue of Genes & Developme...

Descripción completa

Detalles Bibliográficos
Autores principales: Izumi, Natsuko, Tomari, Yukihide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015490/
https://www.ncbi.nlm.nih.gov/pubmed/24696451
http://dx.doi.org/10.1101/gad.241323.114
_version_ 1782315344495378432
author Izumi, Natsuko
Tomari, Yukihide
author_facet Izumi, Natsuko
Tomari, Yukihide
author_sort Izumi, Natsuko
collection PubMed
description The PIWI-interacting RNA (piRNA) pathway protects animal germline cells from transposable elements and other genomic invaders. Although the genome defense function of piRNAs has been well established, the mechanisms of their biogenesis remain poorly understood. In this issue of Genes & Development, three groups identify novel factors required for piRNA biogenesis in Caenorhabditis elegans. These works greatly expand our understanding of the piRNA pathway in worms, highlighting both its shared and its unique properties.
format Online
Article
Text
id pubmed-4015490
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Cold Spring Harbor Laboratory Press
record_format MEDLINE/PubMed
spelling pubmed-40154902014-10-01 Diversity of the piRNA pathway for nonself silencing: worm-specific piRNA biogenesis factors Izumi, Natsuko Tomari, Yukihide Genes Dev Perspective The PIWI-interacting RNA (piRNA) pathway protects animal germline cells from transposable elements and other genomic invaders. Although the genome defense function of piRNAs has been well established, the mechanisms of their biogenesis remain poorly understood. In this issue of Genes & Development, three groups identify novel factors required for piRNA biogenesis in Caenorhabditis elegans. These works greatly expand our understanding of the piRNA pathway in worms, highlighting both its shared and its unique properties. Cold Spring Harbor Laboratory Press 2014-04-01 /pmc/articles/PMC4015490/ /pubmed/24696451 http://dx.doi.org/10.1101/gad.241323.114 Text en © 2014 Izumi and Tomari; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Perspective
Izumi, Natsuko
Tomari, Yukihide
Diversity of the piRNA pathway for nonself silencing: worm-specific piRNA biogenesis factors
title Diversity of the piRNA pathway for nonself silencing: worm-specific piRNA biogenesis factors
title_full Diversity of the piRNA pathway for nonself silencing: worm-specific piRNA biogenesis factors
title_fullStr Diversity of the piRNA pathway for nonself silencing: worm-specific piRNA biogenesis factors
title_full_unstemmed Diversity of the piRNA pathway for nonself silencing: worm-specific piRNA biogenesis factors
title_short Diversity of the piRNA pathway for nonself silencing: worm-specific piRNA biogenesis factors
title_sort diversity of the pirna pathway for nonself silencing: worm-specific pirna biogenesis factors
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015490/
https://www.ncbi.nlm.nih.gov/pubmed/24696451
http://dx.doi.org/10.1101/gad.241323.114
work_keys_str_mv AT izuminatsuko diversityofthepirnapathwayfornonselfsilencingwormspecificpirnabiogenesisfactors
AT tomariyukihide diversityofthepirnapathwayfornonselfsilencingwormspecificpirnabiogenesisfactors

Ejemplares similares