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Histone variants: dynamic punctuation in transcription
Eukaryotic gene regulation involves a balance between packaging of the genome into nucleosomes and enabling access to regulatory proteins and RNA polymerase. Nucleosomes are integral components of gene regulation that restrict access to both regulatory sequences and the underlying template. Whereas...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015494/ https://www.ncbi.nlm.nih.gov/pubmed/24696452 http://dx.doi.org/10.1101/gad.238873.114 |
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author | Weber, Christopher M. Henikoff, Steven |
author_facet | Weber, Christopher M. Henikoff, Steven |
author_sort | Weber, Christopher M. |
collection | PubMed |
description | Eukaryotic gene regulation involves a balance between packaging of the genome into nucleosomes and enabling access to regulatory proteins and RNA polymerase. Nucleosomes are integral components of gene regulation that restrict access to both regulatory sequences and the underlying template. Whereas canonical histones package the newly replicated genome, they can be replaced with histone variants that alter nucleosome structure, stability, dynamics, and, ultimately, DNA accessibility. Here we consider how histone variants and their interacting partners are involved in transcriptional regulation through the creation of unique chromatin states. |
format | Online Article Text |
id | pubmed-4015494 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-40154942014-05-09 Histone variants: dynamic punctuation in transcription Weber, Christopher M. Henikoff, Steven Genes Dev Review Eukaryotic gene regulation involves a balance between packaging of the genome into nucleosomes and enabling access to regulatory proteins and RNA polymerase. Nucleosomes are integral components of gene regulation that restrict access to both regulatory sequences and the underlying template. Whereas canonical histones package the newly replicated genome, they can be replaced with histone variants that alter nucleosome structure, stability, dynamics, and, ultimately, DNA accessibility. Here we consider how histone variants and their interacting partners are involved in transcriptional regulation through the creation of unique chromatin states. Cold Spring Harbor Laboratory Press 2014-04-01 /pmc/articles/PMC4015494/ /pubmed/24696452 http://dx.doi.org/10.1101/gad.238873.114 Text en © 2014 Weber and Henikoff; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by/4.0/ This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0. |
spellingShingle | Review Weber, Christopher M. Henikoff, Steven Histone variants: dynamic punctuation in transcription |
title | Histone variants: dynamic punctuation in transcription |
title_full | Histone variants: dynamic punctuation in transcription |
title_fullStr | Histone variants: dynamic punctuation in transcription |
title_full_unstemmed | Histone variants: dynamic punctuation in transcription |
title_short | Histone variants: dynamic punctuation in transcription |
title_sort | histone variants: dynamic punctuation in transcription |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015494/ https://www.ncbi.nlm.nih.gov/pubmed/24696452 http://dx.doi.org/10.1101/gad.238873.114 |
work_keys_str_mv | AT weberchristopherm histonevariantsdynamicpunctuationintranscription AT henikoffsteven histonevariantsdynamicpunctuationintranscription |