Cargando…

Histone variants: dynamic punctuation in transcription

Eukaryotic gene regulation involves a balance between packaging of the genome into nucleosomes and enabling access to regulatory proteins and RNA polymerase. Nucleosomes are integral components of gene regulation that restrict access to both regulatory sequences and the underlying template. Whereas...

Descripción completa

Detalles Bibliográficos
Autores principales: Weber, Christopher M., Henikoff, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015494/
https://www.ncbi.nlm.nih.gov/pubmed/24696452
http://dx.doi.org/10.1101/gad.238873.114
_version_ 1782315345383522304
author Weber, Christopher M.
Henikoff, Steven
author_facet Weber, Christopher M.
Henikoff, Steven
author_sort Weber, Christopher M.
collection PubMed
description Eukaryotic gene regulation involves a balance between packaging of the genome into nucleosomes and enabling access to regulatory proteins and RNA polymerase. Nucleosomes are integral components of gene regulation that restrict access to both regulatory sequences and the underlying template. Whereas canonical histones package the newly replicated genome, they can be replaced with histone variants that alter nucleosome structure, stability, dynamics, and, ultimately, DNA accessibility. Here we consider how histone variants and their interacting partners are involved in transcriptional regulation through the creation of unique chromatin states.
format Online
Article
Text
id pubmed-4015494
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Cold Spring Harbor Laboratory Press
record_format MEDLINE/PubMed
spelling pubmed-40154942014-05-09 Histone variants: dynamic punctuation in transcription Weber, Christopher M. Henikoff, Steven Genes Dev Review Eukaryotic gene regulation involves a balance between packaging of the genome into nucleosomes and enabling access to regulatory proteins and RNA polymerase. Nucleosomes are integral components of gene regulation that restrict access to both regulatory sequences and the underlying template. Whereas canonical histones package the newly replicated genome, they can be replaced with histone variants that alter nucleosome structure, stability, dynamics, and, ultimately, DNA accessibility. Here we consider how histone variants and their interacting partners are involved in transcriptional regulation through the creation of unique chromatin states. Cold Spring Harbor Laboratory Press 2014-04-01 /pmc/articles/PMC4015494/ /pubmed/24696452 http://dx.doi.org/10.1101/gad.238873.114 Text en © 2014 Weber and Henikoff; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by/4.0/ This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0.
spellingShingle Review
Weber, Christopher M.
Henikoff, Steven
Histone variants: dynamic punctuation in transcription
title Histone variants: dynamic punctuation in transcription
title_full Histone variants: dynamic punctuation in transcription
title_fullStr Histone variants: dynamic punctuation in transcription
title_full_unstemmed Histone variants: dynamic punctuation in transcription
title_short Histone variants: dynamic punctuation in transcription
title_sort histone variants: dynamic punctuation in transcription
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015494/
https://www.ncbi.nlm.nih.gov/pubmed/24696452
http://dx.doi.org/10.1101/gad.238873.114
work_keys_str_mv AT weberchristopherm histonevariantsdynamicpunctuationintranscription
AT henikoffsteven histonevariantsdynamicpunctuationintranscription