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Insulin gene mutations and diabetes

Some mutations of the insulin gene cause hyperinsulinemia or hyperproinsulinemia. Replacement of biologically important amino acid leads to defective receptor binding, longer half‐life and hyperinsulinemia. Three mutant insulins have been identified: (i) insulin Chicago (F49L or PheB25Leu); (ii) ins...

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Detalles Bibliográficos
Autores principales:	Nishi, Masahiro, Nanjo, Kishio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2011
Materias:	Review Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015537/ https://www.ncbi.nlm.nih.gov/pubmed/24843467 http://dx.doi.org/10.1111/j.2040-1124.2011.00100.x

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