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Non-coding-regulatory regions of human brain genes delineated by bacterial artificial chromosome knock-in mice
BACKGROUND: The next big challenge in human genetics is understanding the 98% of the genome that comprises non-coding DNA. Hidden in this DNA are sequences critical for gene regulation, and new experimental strategies are needed to understand the functional role of gene-regulation sequences in healt...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015596/ https://www.ncbi.nlm.nih.gov/pubmed/24124870 http://dx.doi.org/10.1186/1741-7007-11-106 |