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FELD better not thinking of metastases only when liver lesions appear after bleomycin-based treatment for non-seminoma testis from metastases

BACKGROUND: Bleomycin has become an integral part of chemotherapy in patients with germ-cell tumors. One of the most feared side effects is bleomycin-induced pneumonitis. In patients with mild or moderate BIP, radiological signs disappear almost completely within nine months after discontinuation of...

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Autores principales: De Vos, Filip YFL, Mulder, Sasja F, Drenth, Joost PH, Nagtegaal, Iris D, Fütterer, Jurgen J, van der Graaf, Winette TA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015643/
https://www.ncbi.nlm.nih.gov/pubmed/24148527
http://dx.doi.org/10.1186/1471-2407-13-491
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author De Vos, Filip YFL
Mulder, Sasja F
Drenth, Joost PH
Nagtegaal, Iris D
Fütterer, Jurgen J
van der Graaf, Winette TA
author_facet De Vos, Filip YFL
Mulder, Sasja F
Drenth, Joost PH
Nagtegaal, Iris D
Fütterer, Jurgen J
van der Graaf, Winette TA
author_sort De Vos, Filip YFL
collection PubMed
description BACKGROUND: Bleomycin has become an integral part of chemotherapy in patients with germ-cell tumors. One of the most feared side effects is bleomycin-induced pneumonitis. In patients with mild or moderate BIP, radiological signs disappear almost completely within nine months after discontinuation of bleomycin treatment. CASE PRESENTATION: We present a patient with a history of non seminoma of the testis and bleomycin-induced pneumonitis. During follow-up, regression of the hypothesis of eosinophilic migration to the liver after regression of bleomycin-induced pneumonitis is highly suspicious based on transient eosinophilia and focal eosinophilic liver disease. CONCLUSION: As follow up may consist of CT scanning in germ-line tumor patients, transient eosinophilic liver lesions reported during regressive bleomycin-induced pneumonitis should not be presumed automatically as metastatic tumor relapse and require further sequential imaging and pathological examination.
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spelling pubmed-40156432014-05-10 FELD better not thinking of metastases only when liver lesions appear after bleomycin-based treatment for non-seminoma testis from metastases De Vos, Filip YFL Mulder, Sasja F Drenth, Joost PH Nagtegaal, Iris D Fütterer, Jurgen J van der Graaf, Winette TA BMC Cancer Case Report BACKGROUND: Bleomycin has become an integral part of chemotherapy in patients with germ-cell tumors. One of the most feared side effects is bleomycin-induced pneumonitis. In patients with mild or moderate BIP, radiological signs disappear almost completely within nine months after discontinuation of bleomycin treatment. CASE PRESENTATION: We present a patient with a history of non seminoma of the testis and bleomycin-induced pneumonitis. During follow-up, regression of the hypothesis of eosinophilic migration to the liver after regression of bleomycin-induced pneumonitis is highly suspicious based on transient eosinophilia and focal eosinophilic liver disease. CONCLUSION: As follow up may consist of CT scanning in germ-line tumor patients, transient eosinophilic liver lesions reported during regressive bleomycin-induced pneumonitis should not be presumed automatically as metastatic tumor relapse and require further sequential imaging and pathological examination. BioMed Central 2013-10-22 /pmc/articles/PMC4015643/ /pubmed/24148527 http://dx.doi.org/10.1186/1471-2407-13-491 Text en Copyright © 2013 De Vos et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
De Vos, Filip YFL
Mulder, Sasja F
Drenth, Joost PH
Nagtegaal, Iris D
Fütterer, Jurgen J
van der Graaf, Winette TA
FELD better not thinking of metastases only when liver lesions appear after bleomycin-based treatment for non-seminoma testis from metastases
title FELD better not thinking of metastases only when liver lesions appear after bleomycin-based treatment for non-seminoma testis from metastases
title_full FELD better not thinking of metastases only when liver lesions appear after bleomycin-based treatment for non-seminoma testis from metastases
title_fullStr FELD better not thinking of metastases only when liver lesions appear after bleomycin-based treatment for non-seminoma testis from metastases
title_full_unstemmed FELD better not thinking of metastases only when liver lesions appear after bleomycin-based treatment for non-seminoma testis from metastases
title_short FELD better not thinking of metastases only when liver lesions appear after bleomycin-based treatment for non-seminoma testis from metastases
title_sort feld better not thinking of metastases only when liver lesions appear after bleomycin-based treatment for non-seminoma testis from metastases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015643/
https://www.ncbi.nlm.nih.gov/pubmed/24148527
http://dx.doi.org/10.1186/1471-2407-13-491
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