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Ischemic heart disease is associated with vertebral fractures in patients with type 2 diabetes mellitus

AIMS/INTRODUCTION: Discordant results about the relationship between diabetes complications and the risk of fragility fractures have been reported. Our aims were to analyze the factors related to morphometric vertebral fractures (VFs) in patients with type 2 diabetes mellitus, and to explore the ass...

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Autores principales: Muñoz‐Torres, Manuel, Reyes‐García, Rebeca, García‐Martin, Antonia, Jiménez‐Moleón, José Juan, Gonzalez‐Ramírez, Amanda Rocío, Lara‐Villoslada, María Jesús, Moreno, Pedro Rozas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley-Blackwell 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015669/
https://www.ncbi.nlm.nih.gov/pubmed/24843671
http://dx.doi.org/10.1111/jdi.12034
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author Muñoz‐Torres, Manuel
Reyes‐García, Rebeca
García‐Martin, Antonia
Jiménez‐Moleón, José Juan
Gonzalez‐Ramírez, Amanda Rocío
Lara‐Villoslada, María Jesús
Moreno, Pedro Rozas
author_facet Muñoz‐Torres, Manuel
Reyes‐García, Rebeca
García‐Martin, Antonia
Jiménez‐Moleón, José Juan
Gonzalez‐Ramírez, Amanda Rocío
Lara‐Villoslada, María Jesús
Moreno, Pedro Rozas
author_sort Muñoz‐Torres, Manuel
collection PubMed
description AIMS/INTRODUCTION: Discordant results about the relationship between diabetes complications and the risk of fragility fractures have been reported. Our aims were to analyze the factors related to morphometric vertebral fractures (VFs) in patients with type 2 diabetes mellitus, and to explore the association between the presence of VFs and the main cardiovascular risk factors. MATERIALS AND METHODS: We carried out a cross‐sectional study including 123 patients with type 2 diabetes mellitus, and in 72 of these patients we recorded data about the risk factors for VFs and comorbidities of diabetes including diabetes‐related microvascular disease and cardiovascular disease. RESULTS: In the crude analysis, diabetic retinopathy (odds ratio [OR] 4.09, 95% confidence interval [CI] 1.01–12.5), ischemic heart disease (OR 5.02, 95% CI 1.1–9.7) and waist circumference (OR 1.06, 95% CI 1.006–1.114) were related to VFs. In the full model (adjusted for age, sex, body mass index), ischemic heart disease was the only determinant of VF (OR 3.33, CI 1.02–10.91, P = 0.047); whereas diabetic retinopathy did not reached significance (OR 2.27, CI 0.71–7.27, P = 0.16). CONCLUSIONS: In summary, ischemic heart disease is associated with an increased risk of VFs in type 2 diabetes mellitus.
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spelling pubmed-40156692014-05-19 Ischemic heart disease is associated with vertebral fractures in patients with type 2 diabetes mellitus Muñoz‐Torres, Manuel Reyes‐García, Rebeca García‐Martin, Antonia Jiménez‐Moleón, José Juan Gonzalez‐Ramírez, Amanda Rocío Lara‐Villoslada, María Jesús Moreno, Pedro Rozas J Diabetes Investig Articles AIMS/INTRODUCTION: Discordant results about the relationship between diabetes complications and the risk of fragility fractures have been reported. Our aims were to analyze the factors related to morphometric vertebral fractures (VFs) in patients with type 2 diabetes mellitus, and to explore the association between the presence of VFs and the main cardiovascular risk factors. MATERIALS AND METHODS: We carried out a cross‐sectional study including 123 patients with type 2 diabetes mellitus, and in 72 of these patients we recorded data about the risk factors for VFs and comorbidities of diabetes including diabetes‐related microvascular disease and cardiovascular disease. RESULTS: In the crude analysis, diabetic retinopathy (odds ratio [OR] 4.09, 95% confidence interval [CI] 1.01–12.5), ischemic heart disease (OR 5.02, 95% CI 1.1–9.7) and waist circumference (OR 1.06, 95% CI 1.006–1.114) were related to VFs. In the full model (adjusted for age, sex, body mass index), ischemic heart disease was the only determinant of VF (OR 3.33, CI 1.02–10.91, P = 0.047); whereas diabetic retinopathy did not reached significance (OR 2.27, CI 0.71–7.27, P = 0.16). CONCLUSIONS: In summary, ischemic heart disease is associated with an increased risk of VFs in type 2 diabetes mellitus. Wiley-Blackwell 2013-03-01 2013-05-06 /pmc/articles/PMC4015669/ /pubmed/24843671 http://dx.doi.org/10.1111/jdi.12034 Text en © 2013 Asian Association for the Study of Diabetes and Wiley Publishing Asia Pty Ltd
spellingShingle Articles
Muñoz‐Torres, Manuel
Reyes‐García, Rebeca
García‐Martin, Antonia
Jiménez‐Moleón, José Juan
Gonzalez‐Ramírez, Amanda Rocío
Lara‐Villoslada, María Jesús
Moreno, Pedro Rozas
Ischemic heart disease is associated with vertebral fractures in patients with type 2 diabetes mellitus
title Ischemic heart disease is associated with vertebral fractures in patients with type 2 diabetes mellitus
title_full Ischemic heart disease is associated with vertebral fractures in patients with type 2 diabetes mellitus
title_fullStr Ischemic heart disease is associated with vertebral fractures in patients with type 2 diabetes mellitus
title_full_unstemmed Ischemic heart disease is associated with vertebral fractures in patients with type 2 diabetes mellitus
title_short Ischemic heart disease is associated with vertebral fractures in patients with type 2 diabetes mellitus
title_sort ischemic heart disease is associated with vertebral fractures in patients with type 2 diabetes mellitus
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4015669/
https://www.ncbi.nlm.nih.gov/pubmed/24843671
http://dx.doi.org/10.1111/jdi.12034
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